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<p>This experiment aimed to compare the efficacy of an antimicrobial peptide (AMP) with a conventional antibiotic growth promoter (AGP) during necrotic enteritis (NE) challenge in broilers. In total, 720 1-day-old exclusively male broiler chicks (Ross-308) were allocated to five treatments, each with six replicates of 24 birds (<i>n</i> = 144/treatment), for 35 days. The treatments were as follows: (1) uninfected control (UC) with basal diet, (2) infected control (IC) with <i>C. perfringens</i> challenge and basal diet, (3) CP-AGP with <i>C. perfringens</i> challenge and 200 g/ton enramycin throughout trial, (4) CP-AMP1 with <i>C. perfringens</i> challenge and 200 g/ton AMP in all phases, and (5) CP-AMP2 with <i>C. perfringens</i> challenge and 300 g/ton AMP throughout experiment. To induce NE, the birds were predisposed with 10 × coccidia vaccine (day 15) followed by oral gavage of <i>C. perfringens</i> type G (1 ml; 1 × 10<sup>8</sup> CFU/ml/bird) at days 19 and 20. The results showed that AMP supplemented at 300 g/ton of diet improved body weight gain and FCR in both non-challenge (days 1–14) and challenge phases (days 15–35) as compared to the infected control (<i>P</i> &lt; 0.05). Moreover, it also enhanced the livability and production efficiency factor (<i>P</i> &lt; 0.0001). AMP at 300 g/ton also reduced NE lesion scores, and coccidia oocyst shedding, and positively affected intestinal morphology, gut microbial balance, immune organ weights, and HI titers against Newcastle disease (<i>P</i> &lt; 0.0001). These findings suggest that AMP at 300 g/ton of diet could effectively mitigate NE and may be used as a viable substitute for AGPs in broiler diets during the NE challenge.</p>

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Comparative Effects of Antibiotic and Antimicrobial Peptide on Growth Performance, Gut Morphology, Intestinal Lesion Score, Ileal Microbial Counts, and Immune Status in Broilers Challenged with Necrotic Enteritis

  • 期刊论文

  • 发表日期：

    2025年1月10日

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  • Muhammad Muneeb,
  • Ehsaan Ullah Khan,
  • Mubashar Ali,
  • Muhammad Naveed Ul Haque,
  • Muhammad Umar Zafar Khan,
  • Sohail Ahmad

摘要

This experiment aimed to compare the efficacy of an antimicrobial peptide (AMP) with a conventional antibiotic growth promoter (AGP) during necrotic enteritis (NE) challenge in broilers. In total, 720 1-day-old exclusively male broiler chicks (Ross-308) were allocated to five treatments, each with six replicates of 24 birds (n = 144/treatment), for 35 days. The treatments were as follows: (1) uninfected control (UC) with basal diet, (2) infected control (IC) with C. perfringens challenge and basal diet, (3) CP-AGP with C. perfringens challenge and 200 g/ton enramycin throughout trial, (4) CP-AMP1 with C. perfringens challenge and 200 g/ton AMP in all phases, and (5) CP-AMP2 with C. perfringens challenge and 300 g/ton AMP throughout experiment. To induce NE, the birds were predisposed with 10 × coccidia vaccine (day 15) followed by oral gavage of C. perfringens type G (1 ml; 1 × 108 CFU/ml/bird) at days 19 and 20. The results showed that AMP supplemented at 300 g/ton of diet improved body weight gain and FCR in both non-challenge (days 1–14) and challenge phases (days 15–35) as compared to the infected control (P < 0.05). Moreover, it also enhanced the livability and production efficiency factor (P < 0.0001). AMP at 300 g/ton also reduced NE lesion scores, and coccidia oocyst shedding, and positively affected intestinal morphology, gut microbial balance, immune organ weights, and HI titers against Newcastle disease (P < 0.0001). These findings suggest that AMP at 300 g/ton of diet could effectively mitigate NE and may be used as a viable substitute for AGPs in broiler diets during the NE challenge.