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<p>To avoid the “coffee ring” effect in surface-enhanced Raman scattering (SERS) detection, the smooth and hydrophobic substrate surface is designed to enrich the molecules into a single point for SERS detection. The nanoporous Au&amp;Ag alloy pillars (APs) are fabricated in the microregion using laser direct writing (LDW) and magnetron sputtering techniques, and the size of nanopores is tuned by controlling the duration of the electrochemical etching process. The polydimethylsiloxane (PDMS) monolayer is decorated onto the Si substrate to form a super smooth surface, which drives the probe molecules of low concentration to converge downward to the designed region with the nanoporous Au&amp;Ag APs, thereby significantly enhancing the SERS signal intensity. The SERS platform of Au&amp;Ag nanopores alloy pillars (NAPs) with analyte enrichment function is used to perform biomolecules detection, which realizes the quantitative detection of adenine and adenosine.</p> Graphic abstract <p></p>

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Nanopores-coupled SERS platforms on superslippery surfaces using Au&Ag alloy pillars for biomolecules enrichment and detection

  • 期刊论文

  • 发表日期：

    2025年9月10日

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  • Shuangshuang Zhao,
  • Yongjun Zhang,
  • Jiahong Wen,
  • Liang Hong,
  • Wenshi Zhao,
  • Fan Zhang,
  • Yaxin Wang,
  • Renxian Gao,
  • Kun Zhang,
  • Rufei Cui,
  • Fengyi Zhang,
  • Yang Liu,
  • Shikuan Yang,
  • Xiaoyu Zhao

摘要

To avoid the “coffee ring” effect in surface-enhanced Raman scattering (SERS) detection, the smooth and hydrophobic substrate surface is designed to enrich the molecules into a single point for SERS detection. The nanoporous Au&Ag alloy pillars (APs) are fabricated in the microregion using laser direct writing (LDW) and magnetron sputtering techniques, and the size of nanopores is tuned by controlling the duration of the electrochemical etching process. The polydimethylsiloxane (PDMS) monolayer is decorated onto the Si substrate to form a super smooth surface, which drives the probe molecules of low concentration to converge downward to the designed region with the nanoporous Au&Ag APs, thereby significantly enhancing the SERS signal intensity. The SERS platform of Au&Ag nanopores alloy pillars (NAPs) with analyte enrichment function is used to perform biomolecules detection, which realizes the quantitative detection of adenine and adenosine.

Graphic abstract