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<p>Bacterial infections have seriously impaired the wound healing. Despite numerous antibiotics have been developed to inhibit bacteria, the emergence of antibiotic resistance necessitates a rethinking of the public health crisis. In this study, we introduce the carbon dots derived from metformin and dopamine (MD-CDs) as a novel approach to promote the healing of bacterial-infected wound. Through a hydrothermal reaction, the regularly spherical MD-CDs were prepared. Owing to their inherent antibacterial property, MD-CDs effectively inhibited the wound infection and expedited the transition from the inflammation phase to the healing phase in infected wound. Additionally, MD-CDs enhanced the proliferation and migration of L929 cells, which is crucial for wound tissue regeneration. Following the treatment of infected full-thickness skin wounds, MD-CDs effectively promoted the collagen deposition and regeneration of hair follicle in the healing phase. Consequently, MD-CDs represent a bioactive nanomaterial exhibiting inherent antibacterial, offering a promising alternative for the treatment of infected wounds.</p> Graphical abstract <p></p>

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Metformin/dopamine derived bioactive carbon dots accelerate bacteria-infected wound healing

  • 期刊论文

  • 发表日期：

    2025年8月2日

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  • Cong-Ying Wang,
  • Ying-Ge Shi,
  • Yu-Chen Lin,
  • Zhi-Yong Tang,
  • Si-Yu Lu

摘要

Bacterial infections have seriously impaired the wound healing. Despite numerous antibiotics have been developed to inhibit bacteria, the emergence of antibiotic resistance necessitates a rethinking of the public health crisis. In this study, we introduce the carbon dots derived from metformin and dopamine (MD-CDs) as a novel approach to promote the healing of bacterial-infected wound. Through a hydrothermal reaction, the regularly spherical MD-CDs were prepared. Owing to their inherent antibacterial property, MD-CDs effectively inhibited the wound infection and expedited the transition from the inflammation phase to the healing phase in infected wound. Additionally, MD-CDs enhanced the proliferation and migration of L929 cells, which is crucial for wound tissue regeneration. Following the treatment of infected full-thickness skin wounds, MD-CDs effectively promoted the collagen deposition and regeneration of hair follicle in the healing phase. Consequently, MD-CDs represent a bioactive nanomaterial exhibiting inherent antibacterial, offering a promising alternative for the treatment of infected wounds.

Graphical abstract