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<p>Osteoporotic fractures often exhibit delayed healing and repair difficulties in which the bone immune microenvironment may play a critical role, but direct evidence remains elusive. Recently, magnesium (Mg)-based alloys have emerged as promising biodegradable materials capable of promoting fracture healing. Herein, we performed internal fixation of high-purity Mg implants for osteoporotic fractures and used single-cell studies to investigate and elucidate the cellular heterogeneity and dynamic changes that occurred during osteoporotic fracture repair. We observed an early increase in immature neutrophil numbers, together with anti-inflammatory changes in lymphocytes and macrophages. A cluster of macrophages exhibited pro-angiogenic capabilities activated via the TRPM7/S100A4 pathway. These findings provide new theoretical insights into the biological effects of Mg-based materials on the healing of osteoporotic fractures.</p> Graphical abstract <p></p>

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Ability of magnesium implants to remodel the osteoporotic immune microenvironment in a murine femoral fracture model

  • 期刊论文

  • 发表日期：

    2025年4月22日

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  • Tian-Le Ma,
  • Chun Zhou,
  • Guo-Bin Qi,
  • Chang Jiang,
  • Zeng-Xin Jiang,
  • Xiao Wang,
  • Sen-Bo An,
  • Tao Yu,
  • Xiu-Hui Wang,
  • Yue-Qi Zhang,
  • Kai Chen,
  • Yu-Feng Zheng,
  • Zhe Wang

摘要

Osteoporotic fractures often exhibit delayed healing and repair difficulties in which the bone immune microenvironment may play a critical role, but direct evidence remains elusive. Recently, magnesium (Mg)-based alloys have emerged as promising biodegradable materials capable of promoting fracture healing. Herein, we performed internal fixation of high-purity Mg implants for osteoporotic fractures and used single-cell studies to investigate and elucidate the cellular heterogeneity and dynamic changes that occurred during osteoporotic fracture repair. We observed an early increase in immature neutrophil numbers, together with anti-inflammatory changes in lymphocytes and macrophages. A cluster of macrophages exhibited pro-angiogenic capabilities activated via the TRPM7/S100A4 pathway. These findings provide new theoretical insights into the biological effects of Mg-based materials on the healing of osteoporotic fractures.

Graphical abstract