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<p>The development of the three-component catalytic system for constructing isoindolinones from simple feedstocks is both significant and challenging. In this study, a unique tartrate-linked dimeric samarium-antimonotungstate [Sm<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>(tar)(Sb<sub>2</sub>W<sub>21</sub>O<sub>72</sub>)]<sub>2</sub><sup>20−</sup> (<b>Sm</b><sub><b>4</b></sub><b>tar</b><sub><b>2</b></sub>, H<sub>4</sub>tar = tartaric acid) was synthesized via a one-step method at room temperature using an acetate buffer solution. The dimeric polyanion of <b>Sm</b><sub><b>4</b></sub><b>tar</b><sub><b>2</b></sub> shows a centrosymmetric structure with a parallelogram-like arrangement and comprises two enantiomeric {Sm<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>(Sb<sub>2</sub>W<sub>21</sub>O<sub>72</sub>)} moieties connected by two enantiomeric tar ligands. <b>Sm</b><sub><b>4</b></sub><b>tar</b><sub><b>2</b></sub> demonstrates efficient catalytic activity in the three-component reaction involving 2-acylbenzoic acids, primary amines, and phosphine oxides to form 3,3-disubstituted isoindolinones. The advantages of this catalytic system include simple feedstocks, green and reusable catalyst, and operational simplicity with water as the sole by-product. This finding enables an effective molecular fragment assembly strategy for synthesizing isoindolinone drug precursor skeletons.</p> Graphical abstract <p></p>

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A crystalline Sm(III)-containing antimonotungstate with efficient catalytic activity in three-component reaction for isoindolinones synthesis

  • 期刊论文

  • 发表日期：

    2025年3月7日

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  • Hao-Qi Liu,
  • Jia-Wei Cao,
  • Wei Tang,
  • Zhou-Fu Lin,
  • Ke Li,
  • Wei-Jian Xu,
  • Zhi-Bin Zhang,
  • Yu-Feng Liu,
  • Guo-Ping Yang

摘要

The development of the three-component catalytic system for constructing isoindolinones from simple feedstocks is both significant and challenging. In this study, a unique tartrate-linked dimeric samarium-antimonotungstate [Sm2(H2O)6(tar)(Sb2W21O72)]220− (Sm4tar2, H4tar = tartaric acid) was synthesized via a one-step method at room temperature using an acetate buffer solution. The dimeric polyanion of Sm4tar2 shows a centrosymmetric structure with a parallelogram-like arrangement and comprises two enantiomeric {Sm2(H2O)6(Sb2W21O72)} moieties connected by two enantiomeric tar ligands. Sm4tar2 demonstrates efficient catalytic activity in the three-component reaction involving 2-acylbenzoic acids, primary amines, and phosphine oxides to form 3,3-disubstituted isoindolinones. The advantages of this catalytic system include simple feedstocks, green and reusable catalyst, and operational simplicity with water as the sole by-product. This finding enables an effective molecular fragment assembly strategy for synthesizing isoindolinone drug precursor skeletons.

Graphical abstract