Progress and prospects of chiral nanomaterials for biosensing platforms

Chiral nanomaterials have distinct chiroptical properties of preferential interactions to circularly polarized lights. Chirality-based biosensors have emerged for detection of biomolecules, ions and cells in recent years. This review provides an extensive overview of biosensors based on chiral nanomaterials, starting with approaches to chiral nanomaterials construction in terms of fabrication strategies. Fabrication of chiral nanomaterials and their biosensor applications is presented for different material types, with special emphasis on the role and importance of material properties and signal generation in detection. We assessed the technological prospects of the emerging fields of chiral construction, circularly polarized luminescence, Raman optical activity and so on along with their current challenges. Prospective venues for future research on chiral nanomaterials in fabrication, biosensing, disease diagnosis and treatment are also presented in the review.