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<p>This manuscript delivers a comprehensive computational analysis of a Surface Plasmon Resonance (SPR) sensor designed for the detection of tuberculosis (TB) in blood plasma. The sensor architecture is based on the Kretschmann setup and integrates essential elements such as a calcium fluoride (CaF<sub>2</sub>) prism, copper (Cu), silicon carbide, black phosphorus (BP), and a tailored sensing interface. To assess the sensor’s operational characteristics, sophisticated methodologies including the transfer matrix approach and angular interrogation are utilized at a wavelength of 633&#xa0;nm. The optimized configuration achieves an angular sensitivity of 386.50&#xa0;deg/RIU, D.A&#xa0;1.17&#xa0;deg⁻<sup>1</sup> Q.F 329.91&#xa0;RIU⁻<sup>1</sup>, and LOD&#xa0;10.3 <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="12596_2025_2877_Article_IEq1.gif" Format="GIF" Height="18" Rendition="HTML" Resolution="72" Type="Linedraw" Width="47" /> </InlineMediaObject> <EquationSource Format="TEX">\({\times 10}^{-6}\)</EquationSource> <EquationSource Format="MATHML"><math> <msup> <mrow> <mo>×</mo> <mn>10</mn> </mrow> <mrow> <mo>-</mo> <mn>6</mn> </mrow> </msup> </math></EquationSource> </InlineEquation> across a refractive index span of 1.330–1.350. The investigation explores the sensor’s selectivity and analytical capability by evaluating critical metrics such as detection accuracy, quality factor, figure of merit, and dip-of-figure of merit. The outcomes indicate substantial potential for the advancement of medical diagnostic technologies and represent significant value to the field of materials research.</p>

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Theoretical study of silicon carbide-based surface plasmon resonance sensor for detection of tuberculosis in blood plasma

  • 期刊论文

  • 发表日期：

    2025年8月31日

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  • Avantika Bharti,
  • Ramesh Mishra,
  • Parimal Tiwari,
  • Shambhavi Mudra Shukla,
  • Vipin Sharma

摘要

This manuscript delivers a comprehensive computational analysis of a Surface Plasmon Resonance (SPR) sensor designed for the detection of tuberculosis (TB) in blood plasma. The sensor architecture is based on the Kretschmann setup and integrates essential elements such as a calcium fluoride (CaF2) prism, copper (Cu), silicon carbide, black phosphorus (BP), and a tailored sensing interface. To assess the sensor’s operational characteristics, sophisticated methodologies including the transfer matrix approach and angular interrogation are utilized at a wavelength of 633 nm. The optimized configuration achieves an angular sensitivity of 386.50 deg/RIU, D.A 1.17 deg⁻1 Q.F 329.91 RIU⁻1, and LOD 10.3 \({\times 10}^{-6}\) × 10 - 6 across a refractive index span of 1.330–1.350. The investigation explores the sensor’s selectivity and analytical capability by evaluating critical metrics such as detection accuracy, quality factor, figure of merit, and dip-of-figure of merit. The outcomes indicate substantial potential for the advancement of medical diagnostic technologies and represent significant value to the field of materials research.