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<p>Cancer is the largest cause of sickness and death worldwide, excluding infectious disorders. Chemotherapy agents have severe systemic side effects and progressively lose their therapeutic benefits as the majority of malignancies develop multidrug resistance due to a lack of cancer treatment specialization. Researchers are currently investigating platinum nanoparticles (PtNPs), recently discovered agents, for their potential application in cancer treatment. In this study, PtNPs combined with laser illumination as a recommended photodynamic therapy (PDT) approach to combat liver cancer cells. Created PtNPs using the laser ablation in liquid phase (LALP) technique, then examined and classified their structural makeup using a variety of structural techniques. Two-sided PtNPs with different particle structures and laser beams are utilized via different strengths, intensities, and wavelengths to treat individual liver cancer cells using photodynamic therapy. After being treated with PtNPs and a laser with a power of 300 mW and a wavelength of 635&#xa0;nm, the number of liver cancer cells drops and the membrane permeability rises to 80%. Additionally, the amount of hazardous PtNPs that enter the cell significantly impacts its therapy.</p>

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Wavelength-dependent cytotoxicity of platinum nanoparticles in photodynamic therapy against hepatocellular carcinoma

  • 期刊论文

  • 发表日期：

    2025年4月22日

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  • Nahla Ali Tomah,
  • Marwa Jaleel Mohsin,
  • Thanaa Hasan Yousif

摘要

Cancer is the largest cause of sickness and death worldwide, excluding infectious disorders. Chemotherapy agents have severe systemic side effects and progressively lose their therapeutic benefits as the majority of malignancies develop multidrug resistance due to a lack of cancer treatment specialization. Researchers are currently investigating platinum nanoparticles (PtNPs), recently discovered agents, for their potential application in cancer treatment. In this study, PtNPs combined with laser illumination as a recommended photodynamic therapy (PDT) approach to combat liver cancer cells. Created PtNPs using the laser ablation in liquid phase (LALP) technique, then examined and classified their structural makeup using a variety of structural techniques. Two-sided PtNPs with different particle structures and laser beams are utilized via different strengths, intensities, and wavelengths to treat individual liver cancer cells using photodynamic therapy. After being treated with PtNPs and a laser with a power of 300 mW and a wavelength of 635 nm, the number of liver cancer cells drops and the membrane permeability rises to 80%. Additionally, the amount of hazardous PtNPs that enter the cell significantly impacts its therapy.