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<p>Offering hitherto unheard-of capacity for real-time, label-free detection of disease indicators, Surface Plasmon Reso- nance (SPR) biosensing technology offers a revolutionary development in the field of medical diagnostics. The proposed work offers a thorough analysis of a new SPR biosensor design, carefully optimized via COMSOL Multiphysics simulations and rigorously verified using a large dataset including 1000 different samples. Developed sensor architecture uses carefully crafted gold thin film produced on a BK7 glass prism using advanced magnetron sputtering processes with a 47.3&#xa0;nm optimal thickness. Under well- regulated experimental settings, the sensor exhibits extraordinary sensitivity qualities, with a figure of merit of 108.7 RIU <i>−</i> 1 and an optimal penetration depth of 357.2 nanometers. Maintaining a linear dynamic range spanning from 1.33 to 1.38 RIU, an excellent minimum detectable refractive index change of 5.72 <i>×</i> 10 <i>−</i> 1 RIU by means of thorough electromagnetic calculations and subsequently experimental validation is observed. With a correlation coefficient more than 0.9995, the transmittance properties of the sensor show clear and very consistent changes corresponding to analyte concentrations ranging from 0.1 ng/mL to 100 <i>µ</i>g/mL. With an intra-assay coefficient of variation of 1.8% and an inter-assay coefficient of variation of 2.3%, statistical analysis of the 1000- sample dataset demonstrates extraordinary repeatability, therefore demonstrating the strong dependability of the suggested sensor design for clinical uses.</p>

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Enhanced Sensitivity Based Surface Plasmon Resonance Biosensor For Clinical Applications

  • 期刊论文

  • 发表日期：

    2025年3月18日

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  • Gautam Narayan Nirala,
  • Simarpreet Kaur,
  • Yashaswini P R,
  • Bhukya Arun Kumar,
  • Ibrar Jahan M A

摘要

Offering hitherto unheard-of capacity for real-time, label-free detection of disease indicators, Surface Plasmon Reso- nance (SPR) biosensing technology offers a revolutionary development in the field of medical diagnostics. The proposed work offers a thorough analysis of a new SPR biosensor design, carefully optimized via COMSOL Multiphysics simulations and rigorously verified using a large dataset including 1000 different samples. Developed sensor architecture uses carefully crafted gold thin film produced on a BK7 glass prism using advanced magnetron sputtering processes with a 47.3 nm optimal thickness. Under well- regulated experimental settings, the sensor exhibits extraordinary sensitivity qualities, with a figure of merit of 108.7 RIU − 1 and an optimal penetration depth of 357.2 nanometers. Maintaining a linear dynamic range spanning from 1.33 to 1.38 RIU, an excellent minimum detectable refractive index change of 5.72 × 10 − 1 RIU by means of thorough electromagnetic calculations and subsequently experimental validation is observed. With a correlation coefficient more than 0.9995, the transmittance properties of the sensor show clear and very consistent changes corresponding to analyte concentrations ranging from 0.1 ng/mL to 100 µg/mL. With an intra-assay coefficient of variation of 1.8% and an inter-assay coefficient of variation of 2.3%, statistical analysis of the 1000- sample dataset demonstrates extraordinary repeatability, therefore demonstrating the strong dependability of the suggested sensor design for clinical uses.