Detection of tuberculosis using palladium -tantalum diselenide (Pd-TaSe₂) bases SPR biosensor

This study presents a novel structure to improve the SPR biosensor’s sensitivity that is employed for tuberculosis detection. The structure consists of five layers: CsF prism glass, silver thin film, Pd and the material 2D TaSe₂ layer with sensing medium, it uses an angular interrogation technique. Attenuated total reflection (ATR) and the transfer matrix method (TMM) are used to investigate the highly performance parameters of the biosensors in terms of sensitivity (S), detection accuracy (DA) and figure of merit (FOM). The result of the research is that the sensitivity of the Pd and TaSe₂ hybrid layer is improved, and the full half maximum also increased but decreased in (DA) and (FOM) values. The hybrid Pd and TaSe₂ layer improved sensitivity, the full-at-half maximum has also increased but decreased (DA) and (FOM) values. Analysis of silver thickness effect is also investigated. The highest sensitivity is obtained at 410°/RIU with optimized thicknesses of Ag, Pd, and TaSe₂ of 40 nm, 15 nm, and 1 nm, respectively. The proposed SPR biosensor looks promising for use in various biosensing applications.