Designing and simulating fiber arrangement in the probe of elastic scattering signal to be more efficient

In vivo, disease diagnosis using optical spectroscopy offers a non-invasive method that enables timely decision-making without the need for invasive biopsies. Consequently, there has been significant advancement in the utilization of biomedical optical fibers for various clinical applications, which efficiently collect light returning from the target tissue. This study investigates designing and simulating fiber arrangement in the probe besides the factors that may affect the accuracy of Elastic Scattering Spectroscopy measurements. Specifically, the optimal distance between the fibers used for illuminating and collecting back-scattered light from tissues, the role of clad diameter, and operating wavelength are examined. Electromagnetic field domain analysis is conducted using Finite element analysis to provide valuable insights into the simulation of these factors. This simulation can aid in conceptualizing and developing the appropriate fiber selection for accurate diagnosis and monitoring.