Scholarlink

<p>Estrogens are hormones which have diverse role in female physiology. They and their agonists function by binding to the conventional estrogen receptor α (Erα) and estrogen receptor β (Erβ) and also by way of transmembrane GPER. GPER agonists binding follow a diverse signaling pathway to their actions. The GPER has been known to be intricately associated with female reproductive abnormalities like breast, endometrial and cervical cancers. Xenoestrogens are estrogen agonists which act via GPER in causing multiple cancers through non genomic actions. There have been surmounting evidences in last couple of decades about the role played by xenoestrogens in breast, endometrial and cervical cancers involving GPER. In this review we have put forward a comprehensive data about GPER signaling, binding affinity of GPER to xenoestrogens, with their GPER mediated actions include disruption of endocrine activity, tumorigenic activity, cancer and modulation of immune pathway. There are certain inconclusive results but the role of xenoestrogens in GPER mediated cancers and the function of GPER as possible therapeutic target cannot be overlooked.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

GPER a Potent Target of Xenoestrogens: An Overview on Biological Activity and Mechanism of Action in Cancer and Immunogenic Pathway

  • 期刊论文

  • 发表日期：

    2025年6月19日

查看全文
  • Sumana Das,
  • Sudipta Majumdar nee Paul

摘要

Estrogens are hormones which have diverse role in female physiology. They and their agonists function by binding to the conventional estrogen receptor α (Erα) and estrogen receptor β (Erβ) and also by way of transmembrane GPER. GPER agonists binding follow a diverse signaling pathway to their actions. The GPER has been known to be intricately associated with female reproductive abnormalities like breast, endometrial and cervical cancers. Xenoestrogens are estrogen agonists which act via GPER in causing multiple cancers through non genomic actions. There have been surmounting evidences in last couple of decades about the role played by xenoestrogens in breast, endometrial and cervical cancers involving GPER. In this review we have put forward a comprehensive data about GPER signaling, binding affinity of GPER to xenoestrogens, with their GPER mediated actions include disruption of endocrine activity, tumorigenic activity, cancer and modulation of immune pathway. There are certain inconclusive results but the role of xenoestrogens in GPER mediated cancers and the function of GPER as possible therapeutic target cannot be overlooked.