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<p>Alzheimer’s disease (AD) is a progressive outcome resulting from two pathological alterations, specifically the formation of neurofibrillary tangles and the presence of extracellular amyloid plaques. It leads to the degeneration of neural structures, including the fornix. In this study, a systematic literature review is conducted to examine the changes in the fornix that occur in individuals with mild cognitive impairment (MCI) and AD using structural magnetic resonance (sMR) imaging. PubMed, Scopus and Web of Science databases were comprehensively reviewed from January 2000 to October 2023. Twelve articles were finally obtained after removing the duplicates and following the exclusion criteria. This review clearly indicates that the pathological changes in the fornix in AD condition can be revealed by analysing the sMR images. This work also highlights that the alterations in the fornix region have a strong correlation with the hippocampus and total intracranial volume. Although the segmentation and volumetric analysis of fornix is challenging due to its complex structure, further investigation of this region would improve the understanding of the brain in AD subjects.</p>

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A systemic review on the changes in fornix in MCI and AD conditions measured using structural MR imaging

  • 期刊论文

  • 发表日期：

    2025年1月7日

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  • Ahsan Ali,
  • Jac Fredo Agastinose Ronickom,
  • Ramakrishnan Swaminathan

摘要

Alzheimer’s disease (AD) is a progressive outcome resulting from two pathological alterations, specifically the formation of neurofibrillary tangles and the presence of extracellular amyloid plaques. It leads to the degeneration of neural structures, including the fornix. In this study, a systematic literature review is conducted to examine the changes in the fornix that occur in individuals with mild cognitive impairment (MCI) and AD using structural magnetic resonance (sMR) imaging. PubMed, Scopus and Web of Science databases were comprehensively reviewed from January 2000 to October 2023. Twelve articles were finally obtained after removing the duplicates and following the exclusion criteria. This review clearly indicates that the pathological changes in the fornix in AD condition can be revealed by analysing the sMR images. This work also highlights that the alterations in the fornix region have a strong correlation with the hippocampus and total intracranial volume. Although the segmentation and volumetric analysis of fornix is challenging due to its complex structure, further investigation of this region would improve the understanding of the brain in AD subjects.