Scholarlink

<p>Antibacterial screening of the extracts from marine bacteria collected from Japanese tidal flats led us to focus on <i>Tianweitania aestuarii</i> AFB23-2D1 as a producer of antibiotics active against the Gram-positive bacterium <i>Bacillus subtilis</i>. Bioassay-guided fractionation of the extract from the culture of this bacterium revealed that long-chain <i>N</i>-acylvalines are the main antibacterial components. Their structures were elucidated by the interpretation of spectroscopic data, and the absolute stereochemistry of the component valine was determined to be L by the advanced Marfey’s analysis. To the best of our knowledge, this is the first report for the isolation of <i>N</i>-isopentadecanoylvaline and <i>N</i>-tetradecanoylvaline from nature.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Identification of the antibiotics produced by the marine bacterium Tianweitania aestuarii AFB23-2D1

  • 期刊论文

  • 发表日期：

    2026年2月25日

查看全文
  • Saki Shimada,
  • Reiko Ueoka

摘要

Antibacterial screening of the extracts from marine bacteria collected from Japanese tidal flats led us to focus on Tianweitania aestuarii AFB23-2D1 as a producer of antibiotics active against the Gram-positive bacterium Bacillus subtilis. Bioassay-guided fractionation of the extract from the culture of this bacterium revealed that long-chain N-acylvalines are the main antibacterial components. Their structures were elucidated by the interpretation of spectroscopic data, and the absolute stereochemistry of the component valine was determined to be L by the advanced Marfey’s analysis. To the best of our knowledge, this is the first report for the isolation of N-isopentadecanoylvaline and N-tetradecanoylvaline from nature.