<p>This paper presents a novel mode-based approach to address the leader-following consensus problem of multi-agent systems (MASs) under denial-of-service (DoS) attacks. Given that consensus in MASs heavily depends on communication networks, these systems are inherently vulnerable to cyber attacks, which may disrupt information exchange and degrade overall system performance. Consequently, ensuring secure consensus control under DoS attacks has attracted increasing research interest. To deal with this challenge, this paper introduces a mode-based framework that accounts for multiple types of DoS attack scenarios, along with a corresponding statefeedback controller designed for each mode while considering the agent connectivity. Furthermore, based on the proposed controllers and derived sufficient conditions, an efficient algorithm is developed to improve the performance of our mode-based approach. Eventually, the effectiveness of the proposed approach is demonstrated through two numerical examples and one practical example.</p>