Purification of central dialysis fluid delivery system for hemodialysis: practical training on the east kyushu medical valley project

The number of patients receiving renal replacement therapy in Japan is extremely high. However, high-quality hemodialysis therapy, especially dialysate purification, is made possible by clinical engineers who possess medical qualifications that exist only in Japan. In this study, water purification techniques for dialysate delivery systems were developed through a project aimed at improving the human resource development of biomedical engineers in Thailand over the past 10 years (2013–2023).

The central dialysis fluid delivery system, which delivers a large amount of dialysate to multiple dialysis machines, needs to be endotoxin free. The selection of a disinfectant and endotoxin retentive filter is essential to provide high-quality dialysate for patients undergoing hemodialysis.

Using a high concentration of sodium hypochlorite and peracetic acid could reduce the endotoxin concentration in the dialysate delivery system; however, these disinfectants affected the water flux through the membrane pores of the endotoxin retentive filters.

In this study, we describe the purification of a dialysate delivery system with a focus on overseas healthcare specialists, including biomedical engineers, for simultaneous application to multiple patients receiving hemodialysis therapy.