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<p>Mycotoxins are ubiquitous in cereals and cereal products worldwide, presenting substantial health hazards to both humans and animals. Enzymatic degradation has recently gained prominence as a highly effective, selective, and environmentally friendly approach to neutralizing mycotoxins, converting them into non-toxic or less toxic compounds. Herein, we provide a comprehensive overview of the enzymatic properties and degradation pathways of mycotoxin-degrading enzymes that target major mycotoxins, including aflatoxins (AFs), ochratoxins (OTs), deoxynivalenol (DON), zearalenone (ZEN), and fumonisins (FUMs). The identification of multiple mycotoxin-degrading enzymes, such as peroxidases, laccases, esterases, and oxidoreductases, has paved the way for transforming mycotoxins into less or non-toxic products through diverse pathways, offering a promising avenue for complete detoxification.</p>

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Enzymatic detoxification of major mycotoxins: current status, challenges, and future prospective

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • Qiuhong Zhong,
  • Qinghua Wu,
  • Xiaoli Xu,
  • Wei Wei

摘要

Mycotoxins are ubiquitous in cereals and cereal products worldwide, presenting substantial health hazards to both humans and animals. Enzymatic degradation has recently gained prominence as a highly effective, selective, and environmentally friendly approach to neutralizing mycotoxins, converting them into non-toxic or less toxic compounds. Herein, we provide a comprehensive overview of the enzymatic properties and degradation pathways of mycotoxin-degrading enzymes that target major mycotoxins, including aflatoxins (AFs), ochratoxins (OTs), deoxynivalenol (DON), zearalenone (ZEN), and fumonisins (FUMs). The identification of multiple mycotoxin-degrading enzymes, such as peroxidases, laccases, esterases, and oxidoreductases, has paved the way for transforming mycotoxins into less or non-toxic products through diverse pathways, offering a promising avenue for complete detoxification.