Design and Analysis of Multi-Channel Micro-Bioreagent Dispensing System with Pneumatic Valve Control

High-throughput liquid dispensing technology plays a critical role in modern biological laboratories, especially in high-throughput screening experiments. However, the efficiency and throughput of existing dispensing technologies no longer meet the requirements for such experiments. To address this problem, this paper proposes a solution for a non-contact multi-channel dispensing system based on the principle of pneumatic valve control. The system uses a non-contact dispensing method that effectively reduces reagent contamination while providing rapid liquid dispensing. Pneumatic valve-controlled multi-channel liquid dispensing systems have great potential to increase dispensing throughput and efficiency. This paper proposes using the lumped parameter method to establish a system dynamics model that analyzes the relationship between flow and time. Through simulation analysis, the influencing factors of droplet detachment from the sample needle were analyzed to guide the selection of system pressure and sample needle inner diameter. The experimental results preliminarily determined the uniformity of multi-channel liquid dispensing and the accuracy of the lumped parameter model. The simulation results of the process of detaching the sample needle are basically consistent with the experimental results. These studies can provide guidance for multi-channel dispensing systems based on pneumatic valve control.