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<p>Breast cancer (BC) is one of the most significant threats to women’s health worldwide, affecting one in eight women and causing over 42,250 deaths in 2024. Early detection plays a crucial role in improving patient outcomes, with mammography being the primary screening method most health organizations recommend. This paper highlights the potential of deep learning (DL) in enhancing diagnostic Accuracy and speed. However, despite the promising results of DL models, the increasing complexity of breast cancer data presents a significant challenge in selecting the most relevant features. We propose a robust DL model incorporating transfer learning (TL) and grey wolf optimization (GWO) to enhance BC diagnosis. The architecture is developed by leveraging multiple deep neural networks, including ResNet and Inception, based on convolutional neural networks (CNNs). These networks are fine-tuned using a mammographic image dataset to optimize model weights and parameters for higher classification accuracy. Additionally, the Wisconsin Breast Cancer Dataset (WBCD) is utilized with GWO to refine feature selection further. Experimental results demonstrate that the proposed ensemble method improves robustness, generalization, and detection rates while minimizing false positives and negatives. Large-scale dataset evaluation yielded a precision of 0.942, sensitivity of 0.982, Accuracy of 0.965, and an area under the curve (AUC) value of 0.971. These findings suggest that the proposed framework could significantly enhance patient care and improve healthcare service organization and management.</p>

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Optimized ensemble deep learning approach for accurate breast cancer diagnosis using transfer learning and grey wolf optimization

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Esraa Hassan,
  • Abeer Saber,
  • Shaker El-Sappagh,
  • Nora El-Rashidy

摘要

Breast cancer (BC) is one of the most significant threats to women’s health worldwide, affecting one in eight women and causing over 42,250 deaths in 2024. Early detection plays a crucial role in improving patient outcomes, with mammography being the primary screening method most health organizations recommend. This paper highlights the potential of deep learning (DL) in enhancing diagnostic Accuracy and speed. However, despite the promising results of DL models, the increasing complexity of breast cancer data presents a significant challenge in selecting the most relevant features. We propose a robust DL model incorporating transfer learning (TL) and grey wolf optimization (GWO) to enhance BC diagnosis. The architecture is developed by leveraging multiple deep neural networks, including ResNet and Inception, based on convolutional neural networks (CNNs). These networks are fine-tuned using a mammographic image dataset to optimize model weights and parameters for higher classification accuracy. Additionally, the Wisconsin Breast Cancer Dataset (WBCD) is utilized with GWO to refine feature selection further. Experimental results demonstrate that the proposed ensemble method improves robustness, generalization, and detection rates while minimizing false positives and negatives. Large-scale dataset evaluation yielded a precision of 0.942, sensitivity of 0.982, Accuracy of 0.965, and an area under the curve (AUC) value of 0.971. These findings suggest that the proposed framework could significantly enhance patient care and improve healthcare service organization and management.