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Background <p>Integrated care models that address both the physical and psychological needs of patients with inherited cardiovascular conditions (ICCs) are increasingly recommended to support patient well-being. While existing research has highlighted elevated psychiatric symptomatology in ICCs, prior studies have typically relied on limited psychometric assessments. This study aimed to extend this literature by employing a broader, multi-dimensional approach to assess psychiatric symptoms and interoceptive sensibility in this patient population.</p> Method <p>A hospital-based, cross-sectional study was conducted at a national referral centre, involving 101 ICC patients (48.5% females; <i>M</i><sub>age</sub> = 47.3, <i>SD</i> = 11.1), who completed psychometric assessments. The main psychological domains screened through multiple scales were depression, anxiety, perceived stress, and interoception (PHQ9, GAD7, SCL-90R, MAIA-2).</p> Results <p>The study found significantly higher rates of self-reported depression (24.7%) and anxiety (29.7%) symptomatology in ICC patients compared to general population norms (<i>p</i> &lt; 0.001). Elevated perceived stress levels were reported by 67.3% of the sample, along with higher levels of somatization and paranoid ideation (all <i>p</i> &lt; 0.001). Patients also showed increased interoceptive sensibility, including heightened awareness of body sensations (<i>p</i> = 0.002), greater body listening (<i>p</i> &lt; 0.001), and difficulty regulating unpleasant body sensations (<i>p</i> = 0.017). Exploratory analyses indicated that psychological distress was more pronounced among women and those reporting poor sleep or limited physical activity.</p> Conclusion <p>These findings are consistent with prior evidence suggesting a psychological vulnerability in ICC patients and underscore the importance of considering interoceptive and mental health factors in care planning. Due to the cross-sectional and self-report nature of the study, longitudinal and clinical research is needed to clarify underlying mechanisms.</p>

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Mental Health and Interoceptive Sensibility in Inherited Cardiovascular Conditions: A Clinical Investigation of Psychological and Behavioural Correlates

  • 期刊论文

  • 发表日期：

    2025年10月14日

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  • Vasiliki Varela,
  • Maria Vlachopoulou,
  • Christos Papageorgiou,
  • Alexios Antonopoulos,
  • Antigoni Miliou,
  • Dimitra Koutsilieri,
  • Konstantinos Tsioufis,
  • Charalambos Papageorgiou,
  • Charalambos Vlachopoulos

摘要

Background

Integrated care models that address both the physical and psychological needs of patients with inherited cardiovascular conditions (ICCs) are increasingly recommended to support patient well-being. While existing research has highlighted elevated psychiatric symptomatology in ICCs, prior studies have typically relied on limited psychometric assessments. This study aimed to extend this literature by employing a broader, multi-dimensional approach to assess psychiatric symptoms and interoceptive sensibility in this patient population.

Method

A hospital-based, cross-sectional study was conducted at a national referral centre, involving 101 ICC patients (48.5% females; Mage = 47.3, SD = 11.1), who completed psychometric assessments. The main psychological domains screened through multiple scales were depression, anxiety, perceived stress, and interoception (PHQ9, GAD7, SCL-90R, MAIA-2).

Results

The study found significantly higher rates of self-reported depression (24.7%) and anxiety (29.7%) symptomatology in ICC patients compared to general population norms (p < 0.001). Elevated perceived stress levels were reported by 67.3% of the sample, along with higher levels of somatization and paranoid ideation (all p < 0.001). Patients also showed increased interoceptive sensibility, including heightened awareness of body sensations (p = 0.002), greater body listening (p < 0.001), and difficulty regulating unpleasant body sensations (p = 0.017). Exploratory analyses indicated that psychological distress was more pronounced among women and those reporting poor sleep or limited physical activity.

Conclusion

These findings are consistent with prior evidence suggesting a psychological vulnerability in ICC patients and underscore the importance of considering interoceptive and mental health factors in care planning. Due to the cross-sectional and self-report nature of the study, longitudinal and clinical research is needed to clarify underlying mechanisms.