<p>DISH is a systemic noninflammatory condition with unknown causes, closely linked to factors such as sex, age, environmental influences, genetic predisposition, and changes in medication. In addition, certain medical conditions, including gout, metabolic disorders like type 2 diabetes as well as particular populations have significant effects on the frequency of this disease. The individual examined here was unearthed from Liyarsangbon cemetery in Amlash city, situated in the Guilan, Iran. The individual is estimated to be around 35 to 40 years old. In total, the remains of 48 adults and one child were uncovered, with only one specimen showing evidence of the condition known as DISH. On the basis of preliminary typology of the artifacts discovered and grave types, the site was dated to the Parthian (247 BCE–224 CE) and in few cases to the Sassanid period (224–651 CE). Based on the paleopathological analysis of the sample under investigation, indications of pathological changes in the spine, ribs, sternum, and sacroiliac region were detected. While various potential differential diagnoses like spondyloarthropathies, Paget’s disease, metabolic diseases, and POEMS syndrome could apply to the individual, through the utilization of advanced radiological imaging technique and the established criteria related to the aforementioned conditions, the ultimate diagnosis was determined to be either DISH or eDISH.</p>

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The first report of diffuse idiopathic skeletal hyperostosis (DISH) in the Parthian cemetery of Liyarsangbon, Guilan, Iran

  • Mohammad Reza Eghdami,
  • Majid Gholamzadeh Roudbordeh,
  • Maryam Bozorgnia,
  • Mohammad Hassan Hedayati Omami,
  • Habib Zayeni

摘要

DISH is a systemic noninflammatory condition with unknown causes, closely linked to factors such as sex, age, environmental influences, genetic predisposition, and changes in medication. In addition, certain medical conditions, including gout, metabolic disorders like type 2 diabetes as well as particular populations have significant effects on the frequency of this disease. The individual examined here was unearthed from Liyarsangbon cemetery in Amlash city, situated in the Guilan, Iran. The individual is estimated to be around 35 to 40 years old. In total, the remains of 48 adults and one child were uncovered, with only one specimen showing evidence of the condition known as DISH. On the basis of preliminary typology of the artifacts discovered and grave types, the site was dated to the Parthian (247 BCE–224 CE) and in few cases to the Sassanid period (224–651 CE). Based on the paleopathological analysis of the sample under investigation, indications of pathological changes in the spine, ribs, sternum, and sacroiliac region were detected. While various potential differential diagnoses like spondyloarthropathies, Paget’s disease, metabolic diseases, and POEMS syndrome could apply to the individual, through the utilization of advanced radiological imaging technique and the established criteria related to the aforementioned conditions, the ultimate diagnosis was determined to be either DISH or eDISH.