<p>Dust events have been identified as one of the most significant environmental challenges in the Middle East region during the past decades and creating many difficulties for the inhabitants of the Khuzestan province in southwestern Iran. This study investigates a severe sand and dust storm (SDS) that occurred on July 1–2, 2008, in Khuzestan and its neighboring countries. Satellite images, synoptic analysis, numerical simulation with the WRF-Chem model, and air parcel trajectory using the HYSPLIT model were used for detailed analysis of mentioned dust events. Numerical simulation results demonstrated that about 4.11 Tg dust particles were emitted from the simulation area. Comparing the amount of emitted dust to the deposited dust in Khuzestan province indicates that the massive contribution of dust in Khuzestan originates from the Middle East dust sources. Although Khuzestan province has a share of about 0.11% in dust emission in the study period, it hosts 3.5% of the total deposited dust. According to the results of the synoptic analysis of the event and the backward trajectory of the air parcel using the HYSPLIT model and WRF-Chem results analysis, Upper Mesopotamia and southwestern Iraq were the main dust sources that affected Khuzestan province.</p>