<p>The study is carried out in selected vulnerable localities in terms of shortage in water supply in the White Nile State, Sudan, which include El Salam, Guli, and El Gabalain localities. These locations are either situated on basement rocks or dominated by thick clayey deposits within the NW-trending isolated sedimentary rift basins. The primary goal of this study is to explore the groundwater potential zones in the selected areas. The methods of investigations are based on the integration of the processed satellite gravity data with the ground electrical resistivity survey using winner and Schlumberger configurations. The interpretation of satellite gravity data were done through the Residual Bouguer Anomaly (RBA) and second vertical derivatives (SVD) to define the configuration of the sedimentary basins as water-bearing formations. The high-density rocks are attributed to the basement rocks, where the low-density rocks are related to the sedimentary sequences in the (RBA) maps. The faults, plains, and deep fractures are delineated as sharp boundaries between different gravity anomalies in (VSD) maps. The conducted geo-electrical surveys were done on the gravity data findings, detecting the lateral and vertical variations of sub-surface geology that help to highlight the groundwater occurrences. The high resistivity values ≥ 200 Ώ m refer to the occurrences of basement rocks; the medium resistivity values 20–200 Ώ m refer to the aquifer zones, while the low resistivity values of ≤ 20 Ώ m refer to clayey sediments or to saline water in the region.</p>