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<p>Adequate nutrition is essential to human health, significantly influencing both individual well-being and global public health outcomes. As the prevalence of undernutrition, obesity, and digestive disorders increases, there is an urgent need to deepen our understanding of the digestive processes that facilitate nutrient absorption. The small intestine is central to this process, where mechanical movements and biochemical reactions work together to break down and absorb nutrients. In recent years, Computational Fluid Dynamics (CFD) has become a powerful tool for modeling transport phenomena in complex biological systems such as the small intestine. CFD enables high-resolution modeling of intestinal flow dynamics, mixing behavior, and nutrient transport mechanisms under physiologically relevant conditions, providing valuable insight that complements traditional experimental approaches. This paper reviews the current state of CFD-based research on intestinal flow, mixing, digestion and absorption, emphasizing both scientific progress and engineering relevance. Particular attention is given to the challenges of modeling peristaltic flow, heterogeneous reaction environments, and multiscale transport. We also identify opportunities for advancing CFD applications in digestive modeling, with potential benefits for bio-inspired reactor design, pharmaceutical delivery, and food engineering.</p>

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CFD Modeling of Flow, Mixing, Digestion, and Absorption in the Small Intestine

  • 期刊论文

  • 发表日期：

    2025年8月20日

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  • Tianmin Wang,
  • Siyu Zou,
  • Peng Wu,
  • Renpan Deng,
  • Chaoping Fu,
  • Changyong Li,
  • Ai-Zheng Chen

摘要

Adequate nutrition is essential to human health, significantly influencing both individual well-being and global public health outcomes. As the prevalence of undernutrition, obesity, and digestive disorders increases, there is an urgent need to deepen our understanding of the digestive processes that facilitate nutrient absorption. The small intestine is central to this process, where mechanical movements and biochemical reactions work together to break down and absorb nutrients. In recent years, Computational Fluid Dynamics (CFD) has become a powerful tool for modeling transport phenomena in complex biological systems such as the small intestine. CFD enables high-resolution modeling of intestinal flow dynamics, mixing behavior, and nutrient transport mechanisms under physiologically relevant conditions, providing valuable insight that complements traditional experimental approaches. This paper reviews the current state of CFD-based research on intestinal flow, mixing, digestion and absorption, emphasizing both scientific progress and engineering relevance. Particular attention is given to the challenges of modeling peristaltic flow, heterogeneous reaction environments, and multiscale transport. We also identify opportunities for advancing CFD applications in digestive modeling, with potential benefits for bio-inspired reactor design, pharmaceutical delivery, and food engineering.