<p>Weed pressure at maximum vegetative growth stage in sugarcane has underscored the need to investigate post-emergence herbicides to decrease weed biomass and realize the productivity potential of sugarcane. This study assessed weed and productivity responses to different doses of three-way ready-mix post-emergence herbicide during spring 2017 and 2018 in Department of Agronomy at Punjab Agricultural University, Ludhiana, and spring 2019 and 2020 in PAU Regional Research Station, Kapurthala. The treatments were replicated thrice in randomized complete block design. Results indicated that 2020&#xa0;g a.i. a.i. ha⁻¹ of premix 2,4-D sodium salt 48% plus metribuzin 32% plus chlorimuron 0.8% WDG resulted in 136.2% and 133.9%, 87.9% and 375% and 41.9% and 37.9% reduction of biomass of monocots, dicots and sedges at Kapurthala and Ludhiana, respectively, compared to weedy plots at 60 DAA. Further, this herbicide resulted in 33.7% and 24.5% more millable canes and 38.6% and 35.2% higher cane yield at Kapurthala and Ludhiana, respectively, over unsprayed weedy check. It was concluded that post-emergence application of 2,4-D sodium salt 48% plus metribuzin 32% plus chlorimuron 0.8% WDG at 2020&#xa0;g a.i. a.i. ha⁻¹ effectively control the complex weed flora (monocots, dicots and sedges) and enhanced productivity of sugarcane in Indian sub-tropics.</p>