Scholarlink

<p>Recombinant thrombomodulin (rTM) has emerged as a promising therapeutic option for sepsis-associated disseminated intravascular coagulation (DIC). We report a case of acute cholecystitis complicated by DIC that was successfully managed with perioperative rTM administration in combination with laparoscopic cholecystectomy. The patient, a woman in her sixties, presented with acute cholecystitis and concomitant DIC. rTM therapy was initiated prior to surgery, and emergency laparoscopic cholecystectomy was performed with the application of the Pringle maneuver. The patient rapidly recovered from DIC without perioperative hemorrhagic complications, and this case suggests the feasibility and safety of a therapeutic strategy combining preoperative rTM administration followed by emergency laparoscopic cholecystectomy with the Pringle maneuver.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Application of preoperative recombinant thrombomodulin in emergency laparoscopic cholecystectomy for acute cholecystitis with DIC

  • 期刊论文

  • 发表日期：

    2026年4月18日

查看全文
  • Mitsunobu Arizono,
  • Kenei Furukawa,
  • Koichiro Haruki,
  • Tomohiko Taniai,
  • Mitsuru Yanagaki,
  • Masashi Tsunematsu,
  • Yoshihiro Shirai,
  • Shinji Onda,
  • Michinori Matsumoto,
  • Toru Ikegami

摘要

Recombinant thrombomodulin (rTM) has emerged as a promising therapeutic option for sepsis-associated disseminated intravascular coagulation (DIC). We report a case of acute cholecystitis complicated by DIC that was successfully managed with perioperative rTM administration in combination with laparoscopic cholecystectomy. The patient, a woman in her sixties, presented with acute cholecystitis and concomitant DIC. rTM therapy was initiated prior to surgery, and emergency laparoscopic cholecystectomy was performed with the application of the Pringle maneuver. The patient rapidly recovered from DIC without perioperative hemorrhagic complications, and this case suggests the feasibility and safety of a therapeutic strategy combining preoperative rTM administration followed by emergency laparoscopic cholecystectomy with the Pringle maneuver.