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<p>Primary hepatic liposarcoma is extremely rare. Pleomorphic liposarcoma is a rare subtype of liposarcoma, accounting for approximately 7%–8% of these cases. Surgical resection is currently the standard treatment; however, pleomorphic liposarcoma has a high propensity for recurrence and metastasis, resulting in a poor prognosis. Herein, we report a case of primary hepatic pleomorphic liposarcoma with rupture in a 40-year-old woman who presented with abdominal pain. Imaging revealed multiple hepatic tumors with rupture. A liver biopsy suggested necrotic sarcoma, and Adriamycin–ifosfamide (AI) therapy was initiated; however, the disease progressed, leading to hepatectomy. Gross inspection revealed a cut surface appeared yellow–green and gelatinous. Histologically, the tumor exhibited hyperchromatic, pleomorphic nuclei of various sizes, with many cells showing lipoblast-like morphology and intracytoplasmic lipid droplets. Immunohistochemically, the tumor was positive for S-100 and partially positive for RB but negative for CDK4 and MDM2, consistent with pleomorphic liposarcoma. Postoperatively, residual tumor progression and new lesions were observed. Although AI therapy was resumed, it was discontinued due to febrile neutropenia, and the patient died approximately 4 months after surgery.</p>

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Primary hepatic pleomorphic liposarcoma with rupture

  • 期刊论文

  • 发表日期：

    2026年4月27日

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  • Keiichi Kinowaki,
  • Haruka Kono,
  • Yoshihisa Takahashi,
  • Junichi Shindoh,
  • Koichi Suyama,
  • Toshio Fukusato,
  • Yutaka Takazawa

摘要

Primary hepatic liposarcoma is extremely rare. Pleomorphic liposarcoma is a rare subtype of liposarcoma, accounting for approximately 7%–8% of these cases. Surgical resection is currently the standard treatment; however, pleomorphic liposarcoma has a high propensity for recurrence and metastasis, resulting in a poor prognosis. Herein, we report a case of primary hepatic pleomorphic liposarcoma with rupture in a 40-year-old woman who presented with abdominal pain. Imaging revealed multiple hepatic tumors with rupture. A liver biopsy suggested necrotic sarcoma, and Adriamycin–ifosfamide (AI) therapy was initiated; however, the disease progressed, leading to hepatectomy. Gross inspection revealed a cut surface appeared yellow–green and gelatinous. Histologically, the tumor exhibited hyperchromatic, pleomorphic nuclei of various sizes, with many cells showing lipoblast-like morphology and intracytoplasmic lipid droplets. Immunohistochemically, the tumor was positive for S-100 and partially positive for RB but negative for CDK4 and MDM2, consistent with pleomorphic liposarcoma. Postoperatively, residual tumor progression and new lesions were observed. Although AI therapy was resumed, it was discontinued due to febrile neutropenia, and the patient died approximately 4 months after surgery.