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<p>Gastric neuroendocrine tumors (NETs), derived from enterochromaffin-like cells, commonly exhibit submucosal extension and manifest as submucosal tumor (SMT)-like lesions during endoscopy. We report a rare case of a gastric NET with endoscopical unusual pedunculated and reddish morphology. A 15-mm lesion in the gastric body showed histologically proved to be a grade G2 NET. Endoscopic submucosal dissection was performed, followed by surgery due to lymphatic invasion. Histological examination of the background gastric mucosa in the resected specimen revealed features of autoimmune gastritis, consistent with a type 1 gastric NET according to the Rindi classification. Recognition of such atypical morphology may aid diagnosis.</p>

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A case of gastric neuroendocrine tumor with an unusual morphology

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月16日

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  • Takuya Ohashi,
  • Kenichiro Okimoto,
  • Keisuke Matsusaka,
  • Tomoaki Matsumura,
  • Tsubasa Ishikawa,
  • Hirotaka Oura,
  • Tatsuya Kaneko,
  • Yuki Ohta,
  • Takasi Taida,
  • Jun Kato

摘要

Gastric neuroendocrine tumors (NETs), derived from enterochromaffin-like cells, commonly exhibit submucosal extension and manifest as submucosal tumor (SMT)-like lesions during endoscopy. We report a rare case of a gastric NET with endoscopical unusual pedunculated and reddish morphology. A 15-mm lesion in the gastric body showed histologically proved to be a grade G2 NET. Endoscopic submucosal dissection was performed, followed by surgery due to lymphatic invasion. Histological examination of the background gastric mucosa in the resected specimen revealed features of autoimmune gastritis, consistent with a type 1 gastric NET according to the Rindi classification. Recognition of such atypical morphology may aid diagnosis.