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<p>Background/aims: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor with low malignant potential, though 10–15% may show invasive or metastatic behavior. This study aimed to evaluate the safety and efficacy of endoscopic ultrasound-guided ethanol ablation (EUS-EI) in patients with SPN who were not surgical candidates. Methods: Four patients with SPN who declined or were ineligible for surgery underwent EUS-EI at Aichi Cancer Center. Technical and clinical outcomes, as well as adverse events, were assessed. Results: Technical success was achieved in all patients (100%). Clinical success was observed in three patients (75%), including two with complete ablation and one with significant tumor reduction. No major adverse events or tumor recurrence occurred during follow-up. Conclusions: EUS-EI may be a safe and effective alternative for managing SPN in non-surgical candidates.</p>

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EUS-guided ethanol ablation in patients with solid pseudopapillary neoplasm: a four-case series

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Yousik Myung,
  • Kazuo Hara,
  • Shin Haba,
  • Takamichi Kuwahara,
  • Nozomi Okuno,
  • Hiroki Koda,
  • Indria Melianti,
  • Adwoa Agyei-Nkansah

摘要

Background/aims: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor with low malignant potential, though 10–15% may show invasive or metastatic behavior. This study aimed to evaluate the safety and efficacy of endoscopic ultrasound-guided ethanol ablation (EUS-EI) in patients with SPN who were not surgical candidates. Methods: Four patients with SPN who declined or were ineligible for surgery underwent EUS-EI at Aichi Cancer Center. Technical and clinical outcomes, as well as adverse events, were assessed. Results: Technical success was achieved in all patients (100%). Clinical success was observed in three patients (75%), including two with complete ablation and one with significant tumor reduction. No major adverse events or tumor recurrence occurred during follow-up. Conclusions: EUS-EI may be a safe and effective alternative for managing SPN in non-surgical candidates.