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<p>Mycoplasma pneumoniae (MP) is a common respiratory pathogen, but in addition to respiratory tract infection, it can also involve the nervous system, cardiovascular and so on. Nervous system is the most common extrapulmonary complication of MP infection, with a total incidence of about 0.1%. Opsoclonus-myoclonus-ataxia syndrome (OMAS) associated with MP sensation has been reported, but the number of OMAS has been few, and there are few reports on the clinical characteristics and treatment response of the disease. Since the animal model of extrapulmonary manifestations caused by MP has not been established, the characteristics and treatment of this disease need to be accumulated from clinical patients. Here, we report a 13-year-old boy who presented with opsoclonus, myoclonus, and ataxia after 4 days of cough and fever. In addition, we summarized the characteristics of 9 previously reported MP associated OMAS patients and this patient, compared their clinical features, treatment and prognosis.</p>

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Case Report and Literature Review of Mycoplasma Pneumoniae Associated Opsoclonus-Myoclonus-Ataxia Syndrome

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Ni Mao,
  • Bihong Chen,
  • Xuemin Zhu,
  • Huaiqiang Hu

摘要

Mycoplasma pneumoniae (MP) is a common respiratory pathogen, but in addition to respiratory tract infection, it can also involve the nervous system, cardiovascular and so on. Nervous system is the most common extrapulmonary complication of MP infection, with a total incidence of about 0.1%. Opsoclonus-myoclonus-ataxia syndrome (OMAS) associated with MP sensation has been reported, but the number of OMAS has been few, and there are few reports on the clinical characteristics and treatment response of the disease. Since the animal model of extrapulmonary manifestations caused by MP has not been established, the characteristics and treatment of this disease need to be accumulated from clinical patients. Here, we report a 13-year-old boy who presented with opsoclonus, myoclonus, and ataxia after 4 days of cough and fever. In addition, we summarized the characteristics of 9 previously reported MP associated OMAS patients and this patient, compared their clinical features, treatment and prognosis.