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<p>Antibodies directed against the enzyme diacylglycerol lipase alpha (DAGLA) have been recently discovered to cause a severe autoimmune cerebellar syndrome. We report a patient with DAGLA antibodies with prominent tremor and ataxia occurring in the context of a malignant melanoma, indicating that these antibodies may also occur in paraneoplastic cerebellar degeneration.</p>

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Tremor and Ataxia in Paraneoplastic Anti-Diacylglycerol Lipase Alpha (DAGLA) Cerebellitis

  • 期刊论文

  • 发表日期：

    2025年6月18日

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  • José Fidel Baizabal-Carvallo,
  • Raquel Ruiz-García,
  • Laura Naranjo,
  • Francesc Graus

摘要

Antibodies directed against the enzyme diacylglycerol lipase alpha (DAGLA) have been recently discovered to cause a severe autoimmune cerebellar syndrome. We report a patient with DAGLA antibodies with prominent tremor and ataxia occurring in the context of a malignant melanoma, indicating that these antibodies may also occur in paraneoplastic cerebellar degeneration.