<p>The current study explored the indirect effect of internalizing problems on the association between perfectionism and academic performance, additionally examining differences across gender. Further, researchers examined whether internalizing problems impacted academic outcomes differently for adolescents presenting with self-oriented perfectionism versus socially prescribed perfectionism. Data was collected via electronic surveys from 1,048 racially diverse adolescents (52% Female; 47% Male) from a single school in the Southeast region of the United States. A multi-group path analysis was conducted in Mplus. Gender differences were found. Results suggest that, for girls, internalizing problems have an indirect effect on perfectionism and academic performance for both socially prescribed perfectionism and self-oriented perfectionism. In contrast, for boys, internalizing problems do not have a significant indirect effect on the relationship between perfectionism and academic performance. This suggests that addressing internalizing symptoms in perfectionistic females may lead to increased academic outcomes, whereas this may not be the case for males. Additional key findings and implications are discussed further in the present study.</p>