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<p>A 47-year-old man presented with leukocytosis and absolute lymphocytosis. Peripheral blood smear examination revealed atypical lymphoid cells containing striking Auer rod–like cytoplasmic inclusions, creating a strong morphologic impression of acute promyelocytic leukemia. However, flow cytometry demonstrated a mature monoclonal B cell population lacking myeloid differentiation, and bone marrow biopsy established the diagnosis of marginal zone lymphoma. This rare case highlights a major diagnostic pitfall and underscores that Auer rod–like inclusions are not exclusively restricted to myeloid neoplasms.</p>

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Auer rod–like inclusions in marginal zone lymphoma: a potential diagnostic pitfall

  • 期刊论文

  • 发表日期：

    2026年7月24日

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  • Nour Louati,
  • Imen Krichen,
  • Ines Jedidi,
  • Ikram Ben Amor

摘要

A 47-year-old man presented with leukocytosis and absolute lymphocytosis. Peripheral blood smear examination revealed atypical lymphoid cells containing striking Auer rod–like cytoplasmic inclusions, creating a strong morphologic impression of acute promyelocytic leukemia. However, flow cytometry demonstrated a mature monoclonal B cell population lacking myeloid differentiation, and bone marrow biopsy established the diagnosis of marginal zone lymphoma. This rare case highlights a major diagnostic pitfall and underscores that Auer rod–like inclusions are not exclusively restricted to myeloid neoplasms.