Scholarlink

Background <p>Mixed phenotype acute leukemias (MPALs) account for approximately 2–5% of acute leukemias.</p> Purpose <p>We report a case of MPAL with <i>BCR::ABL1</i> demonstrating striking spatial segregation of B- and T-lymphoblasts involving the bone marrow and cervical lymph node, respectively.</p> Methods <p>Morphologic, immunophenotypic, and genetic characterization&#xa0;were performed.</p> Results <p>These studies identified two distinct lineage-specific blast populations. Molecular studies demonstrated shared genetic features, supporting a common clonal origin.</p> Conclusions <p>This case expands the clinicopathologic spectrum of MPALs and raises the possibility of lineage-restricted differentiation occurring in distinct tissue microenvironments.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Spatially segregated B- and T-lymphoblasts in mixed-phenotype acute leukemia with BCR::ABL1

  • 期刊论文

  • 发表日期：

    2026年6月26日

查看全文
  • Ingrid S. Tam,
  • José-Mario Capo-Chichi,
  • Adam C. Smith,
  • Guillaume Richard-Carpentier,
  • Daniel Xia

摘要

Background

Mixed phenotype acute leukemias (MPALs) account for approximately 2–5% of acute leukemias.

Purpose

We report a case of MPAL with BCR::ABL1 demonstrating striking spatial segregation of B- and T-lymphoblasts involving the bone marrow and cervical lymph node, respectively.

Methods

Morphologic, immunophenotypic, and genetic characterization were performed.

Results

These studies identified two distinct lineage-specific blast populations. Molecular studies demonstrated shared genetic features, supporting a common clonal origin.

Conclusions

This case expands the clinicopathologic spectrum of MPALs and raises the possibility of lineage-restricted differentiation occurring in distinct tissue microenvironments.