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<p>Anaplastic large cell lymphoma (ALCL) is contained within a larger category of aggressive mature T-cell lymphomas. Their subclassification relies on the presence or absence of <i>Anaplastic Lymphoma Kinase</i> (ALK) gene fusions and other molecular alterations. Cases in the head and neck and mouth are uncommon. The aim of this manuscript is to describe the clinicopathological and immunohistochemical features of a series of anaplastic large cell lymphoma (ALCL) affecting the oral cavity. Three cases are included in this series, all of them affecting male patients, with a mean age of 27.7&#xa0;years old. Concomitant involvement of the oral cavity and lymph nodes was known to occur in two cases, while cutaneous lesions were not recorded in any patient. The neoplasms more often presented as solitary or multiple painful swellings in the gingiva. All cases were positive for CD30 expression, and the two cases investigated for CD3 were negative. ALK protein was expressed in two cases, and it was negative in one case. EBER was negative in the two cases investigated. One patient was known to decease despite chemotherapy. In conclusion, oral manifestations of ALCL are very rare and more commonly represent a disseminated disease.</p>

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Oral manifestations of anaplastic large cell lymphoma: clinicopathological features and main immunophenotypic findings of 3 cases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Carla Isabelly Rodrigues-Fernandes,
  • Isabela Assis de Siqueira,
  • Cinthia Veronica Bardález López de Cáceres,
  • Juan Manuel Arteaga Legarrea,
  • Victor Tieghi Neto,
  • Geovana Martins Lopes,
  • Marcelo Cavalcanti da Cruz,
  • Hélder Antônio Rebelo Pontes,
  • Wilson Delgado-Azañero,
  • Guilherme Rossi Assis de Mendonça,
  • Pablo Agustin Vargas,
  • Fábio Luiz Coracin,
  • Felipe Paiva Fonseca

摘要

Anaplastic large cell lymphoma (ALCL) is contained within a larger category of aggressive mature T-cell lymphomas. Their subclassification relies on the presence or absence of Anaplastic Lymphoma Kinase (ALK) gene fusions and other molecular alterations. Cases in the head and neck and mouth are uncommon. The aim of this manuscript is to describe the clinicopathological and immunohistochemical features of a series of anaplastic large cell lymphoma (ALCL) affecting the oral cavity. Three cases are included in this series, all of them affecting male patients, with a mean age of 27.7 years old. Concomitant involvement of the oral cavity and lymph nodes was known to occur in two cases, while cutaneous lesions were not recorded in any patient. The neoplasms more often presented as solitary or multiple painful swellings in the gingiva. All cases were positive for CD30 expression, and the two cases investigated for CD3 were negative. ALK protein was expressed in two cases, and it was negative in one case. EBER was negative in the two cases investigated. One patient was known to decease despite chemotherapy. In conclusion, oral manifestations of ALCL are very rare and more commonly represent a disseminated disease.