Scholarlink

Introduction <p>Splenic hamartomas are rare, benign nodular lesions composed of disorganized, sinusoid-like vascular structures within the splenic parenchyma. Occasionally, these lesions may harbor scattered bizarre stromal cells.</p> Case report <p>A 47-year-old female presented with epigastric pain. Imaging (US and CT) revealed a complex cystic lesion in the midline of the spleen. Histological examination showed irregular vascular channels lacking white pulp, interspersed with solitary bizarre stromal cells featuring vesicular chromatin and scant cytoplasm. No mitotic activity or infiltrative growth was identified. Immunohistochemically, the vascular components were CD31, CD34, and CD8 positive. The bizarre stromal cells expressed vimentin, WT-1, cyclin D1, and OCT-4, while remaining negative for Ki-67. A diagnosis of splenic hamartoma with bizarre stromal cells was rendered.</p> Conclusion <p>Splenic hamartoma with bizarre stromal cells is exceedingly rare, with only seven cases previously reported in the English literature. These atypical cells can mimic malignancy, posing a diagnostic challenge. We report this case to highlight these diagnostic pitfalls alongside a literature review.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

What do bizarre cells in the stroma of splenic hamartoma mean? A case report and literature review

  • 期刊论文

  • 发表日期：

    2026年5月20日

查看全文
  • Rabia Hurşitoğlu,
  • Abdulkadir Yasir Bahar,
  • Seda Keskin Gökmen

摘要

Introduction

Splenic hamartomas are rare, benign nodular lesions composed of disorganized, sinusoid-like vascular structures within the splenic parenchyma. Occasionally, these lesions may harbor scattered bizarre stromal cells.

Case report

A 47-year-old female presented with epigastric pain. Imaging (US and CT) revealed a complex cystic lesion in the midline of the spleen. Histological examination showed irregular vascular channels lacking white pulp, interspersed with solitary bizarre stromal cells featuring vesicular chromatin and scant cytoplasm. No mitotic activity or infiltrative growth was identified. Immunohistochemically, the vascular components were CD31, CD34, and CD8 positive. The bizarre stromal cells expressed vimentin, WT-1, cyclin D1, and OCT-4, while remaining negative for Ki-67. A diagnosis of splenic hamartoma with bizarre stromal cells was rendered.

Conclusion

Splenic hamartoma with bizarre stromal cells is exceedingly rare, with only seven cases previously reported in the English literature. These atypical cells can mimic malignancy, posing a diagnostic challenge. We report this case to highlight these diagnostic pitfalls alongside a literature review.