Background <p>Blood flow restriction (BFR) therapy has emerged as a promising rehabilitation modality to enhance post-operative recovery following knee arthroplasty. This study evaluates the efficacy of BFR rehabilitation in patients undergoing primary total and partial knee arthroplasty compared to standard physiotherapy protocols.</p> Methods <p>A single-center, case-control study was conducted on patients undergoing knee arthroplasty. Participants were divided into two groups: one receiving conventional physiotherapy and the other incorporating BFR rehabilitation. Outcome measures included postoperative range of motion (ROM), quadriceps strength, functional mobility (assessed via the Timed Up and Go test), and patientreported pain and satisfaction scores.</p> Results <p>Patients in the BFR group demonstrated significantly greater improvements in quadriceps strength (p 0.05) and functional mobility compared to the control group. ROM and pain scores also showed favorable trends in the BFR group, indicating enhanced postoperative recovery. No significant adverse effects were reported.</p> Conclusions <p>BFR rehabilitation appears to be an effective adjunct to conventional physiotherapy in enhancing functional recovery after knee arthroplasty. Further large-scale studies are warranted to validate these findings and optimize rehabilitation protocols.</p>