<p>Cultural propagation models frequently fail to account for the emergence, recombination, and persistence of complex memetic structures across divergent interpretive contexts. Conventional memetics, reliant on genetic metaphors of high-fidelity replication, neglects the structural affordances and systemic constraints governing meaning-making within a host ecology. The pharmacophore-reactome framework introduced in the current work recharacterizes memes as structured, interpretable configurations operating within a distributed interpretive environment. Memetic transmission is thus determined not by copying accuracy, but by the binding affinity between substructural sign-motifs and the internalized semiotic architecture of the receiver. Grounded in Peircean triadic logic, this mechanism demonstrates how cultural signs acquire functional utility only through integration into compatible semantic receptors. Such a conceptual shift accommodates selective inhibition, modular recombination, and functional clustering within a heterogeneous and evolving semantic ecology. Shifting the analytical focus from the replicator to the interpretable motif enables the simulation of docking interactions and structure-function prediction within cultural systems. Finally, the model provides a formal basis for explaining memetic resistance and non-linear signal propagation in dynamic digital landscapes.</p>