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<p>Metabolic syndrome (MetS) is characterized by a cluster of metabolic abnormalities that increase the risk of cardiovascular diseases, particularly coronary artery disease (CAD). Genetic factors are known to contribute significantly to the susceptibility to CAD among individuals with MetS. The present hospital-based cross-sectional study was conducted to evaluate the association of biochemical parameters and the rs7901695 polymorphism of the <i>TCF7L2</i> gene in MetS patients with and without CAD. A total of 138 patients diagnosed with MetS were enrolled, including 66 CAD cases and 72 non-CAD controls, recruited from a tertiary care hospital in West Bengal, India. Genotyping of the rs7901695 variant was performed using the PCR-RFLP technique. Comparative analysis revealed that the CAD group had significantly lower median Body Mass Index (<i>P</i> = 0.008), HOMA-IR (<i>P</i> = 0.004), hsCRP (<i>P</i> &lt; 0.001), total cholesterol (<i>P</i> &lt; 0.001), HDL cholesterol (<i>P</i> = 0.009), and LDL cholesterol (<i>P</i> &lt; 0.001) compared to the non-CAD group. These comparatively lower biochemical values observed in the CAD group are likely attributable to ongoing therapeutic interventions, including lipid-lowering and other cardioprotective treatments, among diagnosed CAD patients. Furthermore, statistically significant differences were observed in both genotype (<i>P</i> = 0.0488) and allele frequencies (<i>P</i> = 0.0234) of the rs7901695 polymorphism between CAD and non-CAD groups. These findings suggest that the rs7901695 variant of the <i>TCF7L2</i> gene may act as a genetic predisposing factor for the development of CAD in patients with metabolic syndrome.</p>

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Genetic Association of Transcription Factor 7-Like 2 (TCF7L2) with Coronary Artery Disease among Metabolic Syndrome Cases

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Sampa Debnath,
  • Amrita Karmakar,
  • Sanghamitra Chakraborty,
  • Soma Gupta,
  • Nilanjan Sengupta,
  • Swapan Kumar Halder,
  • Debes Ray,
  • Arindam Biswas

摘要

Metabolic syndrome (MetS) is characterized by a cluster of metabolic abnormalities that increase the risk of cardiovascular diseases, particularly coronary artery disease (CAD). Genetic factors are known to contribute significantly to the susceptibility to CAD among individuals with MetS. The present hospital-based cross-sectional study was conducted to evaluate the association of biochemical parameters and the rs7901695 polymorphism of the TCF7L2 gene in MetS patients with and without CAD. A total of 138 patients diagnosed with MetS were enrolled, including 66 CAD cases and 72 non-CAD controls, recruited from a tertiary care hospital in West Bengal, India. Genotyping of the rs7901695 variant was performed using the PCR-RFLP technique. Comparative analysis revealed that the CAD group had significantly lower median Body Mass Index (P = 0.008), HOMA-IR (P = 0.004), hsCRP (P < 0.001), total cholesterol (P < 0.001), HDL cholesterol (P = 0.009), and LDL cholesterol (P < 0.001) compared to the non-CAD group. These comparatively lower biochemical values observed in the CAD group are likely attributable to ongoing therapeutic interventions, including lipid-lowering and other cardioprotective treatments, among diagnosed CAD patients. Furthermore, statistically significant differences were observed in both genotype (P = 0.0488) and allele frequencies (P = 0.0234) of the rs7901695 polymorphism between CAD and non-CAD groups. These findings suggest that the rs7901695 variant of the TCF7L2 gene may act as a genetic predisposing factor for the development of CAD in patients with metabolic syndrome.