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<p>Diabetic nephropathy (DN), a leading cause of end-stage renal disease, has a substantial impact on the global health burden. Matrix Metalloproteinase-7 (MMP-7), a Zn containing endopeptidase leading to extracellular matrix remodelling linked to renal injury and fibrosis has also been shown to be associated with various diabetic complications in previous studies. Data showing MMP-7 promoter gene single nucleotide polymorphism (SNP) 181&#xa0;A &gt; G altering MMP-7 expression in diabetes and DN is scarce. Thus, present study hypothesized to explore the relation of MMP-7 SNP 181&#xa0;A &gt; G at the promoter region with DN risk and its impact on serum MMP-7 levels. A case-control study was conducted including 183 participants: 61 DN patients as cases, 61 diabetic controls without nephropathy, and 61 healthy controls. Serum MMP-7 levels were estimated using ELISA and MMP-7 181&#xa0;A &gt; G SNP was genotyped using PCR-RFLP. Biochemical parameters were collected from case records. Statistical analysis was done using SPSS-26 version. Significant elevation of serum MMP-7 levels was noted in DN patients compared to controls (p value &lt; 0.001) being correlated with glycaemic status and eGFR (<i>r</i> = -0.65). The 181&#xa0;A &gt; G SNP revealed a significant association with DN risk (OR = 2.22, <i>p</i> &lt; 0.05) in the dominant model (AG + GG vs. AA), having no significant relation with SNP as well as serum MMP-7 levels. Raised serum MMP-7 concentrations are linked with DN and renal dysfunction. The MMP-7 181&#xa0;A &gt; G SNP is a risk factor for DN but has no significant influence on serum MMP-7 level that needs larger prospective trials.</p>

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Exploring the Association of MMP-7 Promoter Site Single Nucleotide Polymorphism with Risk of Diabetic Nephropathy

  • 期刊论文

  • 发表日期：

    2025年8月22日

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  • Chhabi Rani Panda,
  • Manaswini Mangaraj,
  • Sandip Kumar Panda,
  • Suchitra Kumari,
  • Gautom Kumar Saharia,
  • Saurav Nayak

摘要

Diabetic nephropathy (DN), a leading cause of end-stage renal disease, has a substantial impact on the global health burden. Matrix Metalloproteinase-7 (MMP-7), a Zn containing endopeptidase leading to extracellular matrix remodelling linked to renal injury and fibrosis has also been shown to be associated with various diabetic complications in previous studies. Data showing MMP-7 promoter gene single nucleotide polymorphism (SNP) 181 A > G altering MMP-7 expression in diabetes and DN is scarce. Thus, present study hypothesized to explore the relation of MMP-7 SNP 181 A > G at the promoter region with DN risk and its impact on serum MMP-7 levels. A case-control study was conducted including 183 participants: 61 DN patients as cases, 61 diabetic controls without nephropathy, and 61 healthy controls. Serum MMP-7 levels were estimated using ELISA and MMP-7 181 A > G SNP was genotyped using PCR-RFLP. Biochemical parameters were collected from case records. Statistical analysis was done using SPSS-26 version. Significant elevation of serum MMP-7 levels was noted in DN patients compared to controls (p value < 0.001) being correlated with glycaemic status and eGFR (r = -0.65). The 181 A > G SNP revealed a significant association with DN risk (OR = 2.22, p < 0.05) in the dominant model (AG + GG vs. AA), having no significant relation with SNP as well as serum MMP-7 levels. Raised serum MMP-7 concentrations are linked with DN and renal dysfunction. The MMP-7 181 A > G SNP is a risk factor for DN but has no significant influence on serum MMP-7 level that needs larger prospective trials.