Identification of OncoMir Biomarkers: Comprehensive Analysis of Fatty Acid Pathway Genes in Colorectal Cancer Progression and Their Prognostic Implications
摘要
MicroRNAs play a pivotal role in driving colorectal cancer (CRC) progression through their influence on gene expression. In this study, we conducted a comprehensive analysis of gene expression profiles in CRC cell lines, focusing on the genes involved in the fatty acid pathway and their associated microRNAs. Our analysis unveiled a consistent pattern of decreased expression for miR-16-5p, miR-195-5p, miR-27a-3p, and miR-497-5p across all CRC cell lines studied. Intriguingly, the targeted genes showed a contrasting trend, with increased expression levels. To reinforce our findings, we conducted a comparative analysis with The Cancer Genome Atlas database, which corroborated our results. Notably, we found a strong association between high expression levels of PPARD and VEGFA and a shorter Disease-Free Survival (DFS) in CRC patients. Conversely, elevated expression of PPARGC1A was linked to better overall survival outcomes. These findings underscore the significant impact of microRNAs on the regulation of gene expression in colorectal cancer and highlight potential biomarkers for assessing disease progression and patient outcomes.