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<p>An 18-year-old male with beta thalassemia intermedia receiving regular transfusions had left sided occipital hemorrhagic stroke 3 months back, presently having manifestations of dwarfism, generalized weakness, delayed puberty and conducting hearing loss. Besides he had severe anemia, hyperferritinemia, central hypothyroidism, hypogonadotropic hypogonadism, and pituitary hemosiderosis and old occipital hemorrhage in MRI thus highlighting the diverse and potentially underrecognized consequences of transfusional iron overload in β-thalassemia. He was managed with blood transfusion, iron chelation, and hormonal replacement. Recognition of such manifestations is essential for early diagnosis, multidisciplinary management, and prevention of long-term morbidity in patients with chronic transfusion-dependent thalassemia.</p>

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Pituitary Hemosiderosis in a β-Thalassemia Intermedia: A Rare Constellation of Complications

  • 期刊论文

  • 发表日期：

    2026年7月20日

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  • Poonam Gupta,
  • Ajeet Kumar Chaurasia,
  • Ashish Kumar Rai,
  • Ved Prakash Singh,
  • Divya Chutani,
  • Surendra Kumar Gupta

摘要

An 18-year-old male with beta thalassemia intermedia receiving regular transfusions had left sided occipital hemorrhagic stroke 3 months back, presently having manifestations of dwarfism, generalized weakness, delayed puberty and conducting hearing loss. Besides he had severe anemia, hyperferritinemia, central hypothyroidism, hypogonadotropic hypogonadism, and pituitary hemosiderosis and old occipital hemorrhage in MRI thus highlighting the diverse and potentially underrecognized consequences of transfusional iron overload in β-thalassemia. He was managed with blood transfusion, iron chelation, and hormonal replacement. Recognition of such manifestations is essential for early diagnosis, multidisciplinary management, and prevention of long-term morbidity in patients with chronic transfusion-dependent thalassemia.