To investigate the correlation between the dwell time of peripherally inserted central catheters (PICCs) and the risk of catheter-related complications in patients with hematological malignancies. The clinical data of 106 patients who underwent PICC in our hospital from January 2022 to December 2024 were retrospectively analyzed. According to the catheter dwell time, they were divided into short-term group (SG, ≤ 60 days, n = 44), mid-term group (MG, 61–120 days, n = 33), and long-term group (LG, > 120 days, n = 29). The basic characteristics, incidence of catheter-related complications, complication density, time to complication occurrence, distribution of risk factors, and clinical outcomes of the three groups were compared. There were significant differences among the three groups of patients in age, tumor type, hematological indicators, and chemotherapy status (P < 0.05). The overall complication rate increased from 15.91% in the short-term group to 68.97% in the long-term group (P < 0.001). The incidence densities of CRBSI and CRT in the long-term group were 3.04 and 2.61 per 1000 catheter-days, respectively, with relative risks of 2.87 and 3.68. Among patients in the long-term group, 41.38% had ≥ 4 risk factors, significantly higher than 4.55% in the short-term group (P < 0.001). Multivariable logistic regression analysis showed that the dwell time, age ≥ 60 years, neutrophil count < 1.0 × 109/L, platelet count < 50 × 109/L, catheter insertion during chemotherapy, and previous infection history were independent risk factors for catheter-related complications (P < 0.05). In the long-term group, 31.03% of patients underwent premature removal of the PICC due to complications, and the length of hospital stay and the duration of antibiotic use were significantly higher than those in the short-term group (P < 0.001). PICC dwell time is an important factor influencing catheter-related complications in patients with hematological malignancies. Prolonged PICC dwell time may be associated with an increased risk of complications, potentially affecting treatment continuity and clinical outcomes. In clinical practice, the benefits and risks of long-term indwelling should be carefully balanced. Individualized management strategies based on risk-factor assessment and enhanced monitoring and prevention for high-risk patients may help improve patient prognosis and quality of life.

Correlation Between PICC Dwell Time and the Risk of Catheter-Related Complications in Patients with Hematological Malignancies

期刊论文
发表日期：

2026年7月7日

查看全文

Xuemei Zhu,
Xiaolan Luo

摘要

To investigate the correlation between the dwell time of peripherally inserted central catheters (PICCs) and the risk of catheter-related complications in patients with hematological malignancies. The clinical data of 106 patients who underwent PICC in our hospital from January 2022 to December 2024 were retrospectively analyzed. According to the catheter dwell time, they were divided into short-term group (SG, ≤ 60 days, n = 44), mid-term group (MG, 61–120 days, n = 33), and long-term group (LG, > 120 days, n = 29). The basic characteristics, incidence of catheter-related complications, complication density, time to complication occurrence, distribution of risk factors, and clinical outcomes of the three groups were compared. There were significant differences among the three groups of patients in age, tumor type, hematological indicators, and chemotherapy status (P < 0.05). The overall complication rate increased from 15.91% in the short-term group to 68.97% in the long-term group (P < 0.001). The incidence densities of CRBSI and CRT in the long-term group were 3.04 and 2.61 per 1000 catheter-days, respectively, with relative risks of 2.87 and 3.68. Among patients in the long-term group, 41.38% had ≥ 4 risk factors, significantly higher than 4.55% in the short-term group (P < 0.001). Multivariable logistic regression analysis showed that the dwell time, age ≥ 60 years, neutrophil count < 1.0 × 10⁹/L, platelet count < 50 × 10⁹/L, catheter insertion during chemotherapy, and previous infection history were independent risk factors for catheter-related complications (P < 0.05). In the long-term group, 31.03% of patients underwent premature removal of the PICC due to complications, and the length of hospital stay and the duration of antibiotic use were significantly higher than those in the short-term group (P < 0.001). PICC dwell time is an important factor influencing catheter-related complications in patients with hematological malignancies. Prolonged PICC dwell time may be associated with an increased risk of complications, potentially affecting treatment continuity and clinical outcomes. In clinical practice, the benefits and risks of long-term indwelling should be carefully balanced. Individualized management strategies based on risk-factor assessment and enhanced monitoring and prevention for high-risk patients may help improve patient prognosis and quality of life.