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<p>This study aims to evaluate and compare the morphometric parameters of megakaryocytes (MKs) in bone marrow (BM) sections of various myeloproliferative neoplasms (MPNs) disorders, along with a normal histology case. Whole slide scanned microscopic images of hematoxylin and eosin stained two micron thick sections of thirty-one BM biopsy cases were used for the evaluation of: BM cellularity, megakaryocyte (MK) density in BM area, MK density in cellular BM area, MK nuclear area, coefficient of variations (CV) of MK nuclear area, MK nuclear circularity, space occupied by MK nuclei in BM, MK cell area, CV of MK cell area, MK cell circularity, space occupied by MKs in BM, and MK nuclear to cell area ratio. BM cellularity, MK density in the BM area, MK nuclear circularity, space occupied by MK nuclei, and space occupied by MKs in the BM were found significantly higher in MPNs than in the normal histology group. Within the MPNs, the MK nuclear area and space occupied by MK nuclei in BM showed remarkable differences between the groups. The morphometric features of megakaryocytes in hematological neoplasms provide quantitative information that will be helpful for precise diagnosis and understanding of disease progression.</p>

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Quantitative Evaluation of Megakaryocytes in Bone Marrow Biopsy of Myeloproliferative Neoplasms by Morphometry

  • 期刊论文

  • 发表日期：

    2026年5月20日

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  • Gurpreet Kaur Sagoo,
  • Dibyajyoti Boruah,
  • Ankur Ahuja,
  • Barun Kumar Chakrabarty,
  • S. Venkatesan

摘要

This study aims to evaluate and compare the morphometric parameters of megakaryocytes (MKs) in bone marrow (BM) sections of various myeloproliferative neoplasms (MPNs) disorders, along with a normal histology case. Whole slide scanned microscopic images of hematoxylin and eosin stained two micron thick sections of thirty-one BM biopsy cases were used for the evaluation of: BM cellularity, megakaryocyte (MK) density in BM area, MK density in cellular BM area, MK nuclear area, coefficient of variations (CV) of MK nuclear area, MK nuclear circularity, space occupied by MK nuclei in BM, MK cell area, CV of MK cell area, MK cell circularity, space occupied by MKs in BM, and MK nuclear to cell area ratio. BM cellularity, MK density in the BM area, MK nuclear circularity, space occupied by MK nuclei, and space occupied by MKs in the BM were found significantly higher in MPNs than in the normal histology group. Within the MPNs, the MK nuclear area and space occupied by MK nuclei in BM showed remarkable differences between the groups. The morphometric features of megakaryocytes in hematological neoplasms provide quantitative information that will be helpful for precise diagnosis and understanding of disease progression.