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<p>This retrospective single-centre study investigates the transplant-free survival (TFS) and treatment response in patients with T-cell Acute Lymphoblastic Leukemia (T-ALL). Thirty-three patients diagnosed with T-ALL were evaluated for demographic variables, response to induction chemotherapy, measurable residual disease (MRD), relapse rates and long-term survival without hematopoietic stem cell transplantation. MRD &lt; 0.01% post-induction correlated significantly with superior TFS (<i>p</i> = 0.031). Age and sex were not significantly associated with survival. The findings underscore the prognostic value of MRD and early treatment response in guiding T-ALL management without necessitating transplantation under vigilance.</p>

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Measurable Residual Disease-Guided Chemotherapy and Transplant-Free Survival in Adult T-ALL -A Single-Centre Experience from North India

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • P. Raghuveer,
  • Shailendra Prasad Verma,
  • Gaurav Datta,
  • Swasti Sinha,
  • Aritra Saha,
  • Alpika Shukla,
  • Akshay Middinti,
  • Rajkumar Maurya

摘要

This retrospective single-centre study investigates the transplant-free survival (TFS) and treatment response in patients with T-cell Acute Lymphoblastic Leukemia (T-ALL). Thirty-three patients diagnosed with T-ALL were evaluated for demographic variables, response to induction chemotherapy, measurable residual disease (MRD), relapse rates and long-term survival without hematopoietic stem cell transplantation. MRD < 0.01% post-induction correlated significantly with superior TFS (p = 0.031). Age and sex were not significantly associated with survival. The findings underscore the prognostic value of MRD and early treatment response in guiding T-ALL management without necessitating transplantation under vigilance.