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<p>Acute chest syndrome (ACS) and pulmonary hypertension (PH) are major factors of morbidity and mortality in patients with sickle cell disease (SCD). This prospective observational study aimed to evaluate the clinical profile and identify laboratory, radiological, and echocardiographic parameters associated with adverse outcomes in SCD. 120 adults with laboratory-confirmed SCD participated in the study. Clinical assessment, echocardiogram, and relevant laboratory tests were conducted to correlate with patient outcome, and the respective associations were analysed. The study indicated that 32 patients (26.7%) had ACS, and 25 patients (20.8%) had PH. Body ache and fever were the most common symptoms noted in 66.7% of the patients. Normal echocardiogram results were highly associated with good outcomes (<i>p</i> = 0.042). Abnormal echocardiogram results and decreased haemoglobin (OR = 2.5, <i>p</i> = 0.005), among other laboratory abnormalities, were significant predictors of mortality. Echocardiographic and laboratory parameters are strong predictors of adverse outcomes in adult SCD patients. Routine monitoring of these parameters can decrease the complications of ACS and PH in SCD and guide timely clinical management.</p>

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Clinical Characteristics and Outcome Predictors in Adult Patients with Sickle Cell Disease: A Prospective Observational Study

  • 期刊论文

  • 发表日期：

    2026年5月13日

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  • Sanjaykumar Rathwa,
  • Pratiksha Rathwa,
  • Vaibhav Mehta,
  • Sunanda Banerjee,
  • Shifa M. Karatela,
  • Rajesh Sumple

摘要

Acute chest syndrome (ACS) and pulmonary hypertension (PH) are major factors of morbidity and mortality in patients with sickle cell disease (SCD). This prospective observational study aimed to evaluate the clinical profile and identify laboratory, radiological, and echocardiographic parameters associated with adverse outcomes in SCD. 120 adults with laboratory-confirmed SCD participated in the study. Clinical assessment, echocardiogram, and relevant laboratory tests were conducted to correlate with patient outcome, and the respective associations were analysed. The study indicated that 32 patients (26.7%) had ACS, and 25 patients (20.8%) had PH. Body ache and fever were the most common symptoms noted in 66.7% of the patients. Normal echocardiogram results were highly associated with good outcomes (p = 0.042). Abnormal echocardiogram results and decreased haemoglobin (OR = 2.5, p = 0.005), among other laboratory abnormalities, were significant predictors of mortality. Echocardiographic and laboratory parameters are strong predictors of adverse outcomes in adult SCD patients. Routine monitoring of these parameters can decrease the complications of ACS and PH in SCD and guide timely clinical management.