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<p>This study aimed to explore the importance of readily obtainable Red Blood Cell (RBC) indices in persons with normal and variant haemoglobins among non-anaemic volunteers from a rural tertiary care institution in West Bengal. It also focused on identifying non-anaemic healthy carriers of haemoglobinopathies prevalent in this zone. A total of 1054 non-anaemic volunteers (65.3% male, aged 16–46 years) were included after excluding individuals with anaemia, recent transfusions, or on therapy for deficiency anaemias. Blood samples were analysed for haemoglobin levels and RBC indices using automated cell counters, while haemoglobin variants were detected through Cation exchange High-Performance Liquid Chromatography (CE-HPLC). Among the participants, 12.16% (129 out of 1054) exhibited abnormal haemoglobin patterns. The most common variant was the HbE trait (8.58%), followed by the β-thalassemia trait (2.23%), HbA2 in the borderline zone (1.2%), and HbE disease (0.19%). HbE trait was associated with slight microcytic, hypochromic RBCs, with raised peak of HbE, and decreased HbA. β-thalassemia trait showed microcytic, hypochromic RBCs with mildly elevated HbA2 (&gt; 4.0%). Statistically significant differences (<i>p</i> &lt; 0.05) were observed in RBC indices, including RBC count, MCV, MCH, MCHC and RDW, between participants with normal and abnormal haemoglobin patterns. The study highlights the utility of RBC indices as a cost-effective tool for screening of haemoglobinopathy carriers among healthy non anaemic individuals, particularly in high-prevalence regions. Early detection through targeted screening programs can prevent severe conditions such as transfusion dependent thalassemia, underscoring the need for public health interventions in rural communities.</p>

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A Study of RBC Indices and Haemoglobin Variants Among Non-Anaemic Volunteers from a Rural Tertiary Care Institution in West Bengal

  • 期刊论文

  • 发表日期：

    2026年4月22日

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  • Lahiri Aditi,
  • Deb Novonil,
  • Lahiri Pratibha Rao,
  • Goswami Bidyut Krishna

摘要

This study aimed to explore the importance of readily obtainable Red Blood Cell (RBC) indices in persons with normal and variant haemoglobins among non-anaemic volunteers from a rural tertiary care institution in West Bengal. It also focused on identifying non-anaemic healthy carriers of haemoglobinopathies prevalent in this zone. A total of 1054 non-anaemic volunteers (65.3% male, aged 16–46 years) were included after excluding individuals with anaemia, recent transfusions, or on therapy for deficiency anaemias. Blood samples were analysed for haemoglobin levels and RBC indices using automated cell counters, while haemoglobin variants were detected through Cation exchange High-Performance Liquid Chromatography (CE-HPLC). Among the participants, 12.16% (129 out of 1054) exhibited abnormal haemoglobin patterns. The most common variant was the HbE trait (8.58%), followed by the β-thalassemia trait (2.23%), HbA2 in the borderline zone (1.2%), and HbE disease (0.19%). HbE trait was associated with slight microcytic, hypochromic RBCs, with raised peak of HbE, and decreased HbA. β-thalassemia trait showed microcytic, hypochromic RBCs with mildly elevated HbA2 (> 4.0%). Statistically significant differences (p < 0.05) were observed in RBC indices, including RBC count, MCV, MCH, MCHC and RDW, between participants with normal and abnormal haemoglobin patterns. The study highlights the utility of RBC indices as a cost-effective tool for screening of haemoglobinopathy carriers among healthy non anaemic individuals, particularly in high-prevalence regions. Early detection through targeted screening programs can prevent severe conditions such as transfusion dependent thalassemia, underscoring the need for public health interventions in rural communities.