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<p>A 70-year-old male with fatigue and pancytopenia was found to have IgD-lambda multiple myeloma. Initial bone marrow morphology showed blastoid cells, misleadingly suggestive of lymphoma. Diagnosis was established by immunophenotyping (plasma cell phenotype) and cytogenetics, highlighting a critical diagnostic pitfall where cytomorphology contradicted the immunophenotypic findings.</p>

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IgD Myeloma Mimicking Lymphoma: A Diagnostic Pitfall

  • 期刊论文

  • 发表日期：

    2026年4月1日

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  • Linmeng Li,
  • Meixuan Chen,
  • Cuihua Ma,
  • Hongwei Chen

摘要

A 70-year-old male with fatigue and pancytopenia was found to have IgD-lambda multiple myeloma. Initial bone marrow morphology showed blastoid cells, misleadingly suggestive of lymphoma. Diagnosis was established by immunophenotyping (plasma cell phenotype) and cytogenetics, highlighting a critical diagnostic pitfall where cytomorphology contradicted the immunophenotypic findings.