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<p>To investigate the clinical and laboratory characteristics and prognostic factors of patients with extranodal NK/T-cell lymphoma (ENKTCL). A retrospective analysis was conducted on the clinical data and laboratory indicators of patients with ENKTCL with confirmed pathological diagnoses admitted to our hospital between January 2012 and November 2024. The median patient age was 54 years. In univariate analysis, multiple factors including B symptoms, ECOG score (0–1 vs. ≥2), IPI score (0–1 vs. ≥2), KPI score (0–1 vs. ≥2), PINK score (0–1 vs. ≥2), NRI score (0–1 vs. ≥2), Ann Arbor stage (I/II vs. III/IV), primary tumor site (nasal vs. non-nasal), hemoglobin level (&lt; 110 vs. ≥110&#xa0;g/L), and EBV-DNA copy number (&lt; 0.5 vs. ≥0.5 × 10³/ml) were significantly associated with 5-year overall survival (all <i>P</i> &lt; 0.05). Multivariate analysis confirmed that ECOG score ≥ 2, presence of B symptoms, advanced Ann Arbor stage (III/IV), and high EBV-DNA copy number (≥ 0.5 × 10³/ml) were independent prognostic factors for worse survival. ECOG score, B symptoms, Ann Arbor stage, and EBV-DNA load serve as independent prognostic indicators in ENKTCL, providing critical information for risk stratification.</p>

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Clinical and Laboratory Characteristics and Prognostic Analysis of 40 Cases of Extranodal NK/T-cell Lymphoma

  • 期刊论文

  • 发表日期：

    2026年3月24日

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  • Huifang Xiao,
  • Yiping Chen,
  • Pengliang Xin,
  • Jinyan Zhang,
  • Yanjun He,
  • Wenqian Xu

摘要

To investigate the clinical and laboratory characteristics and prognostic factors of patients with extranodal NK/T-cell lymphoma (ENKTCL). A retrospective analysis was conducted on the clinical data and laboratory indicators of patients with ENKTCL with confirmed pathological diagnoses admitted to our hospital between January 2012 and November 2024. The median patient age was 54 years. In univariate analysis, multiple factors including B symptoms, ECOG score (0–1 vs. ≥2), IPI score (0–1 vs. ≥2), KPI score (0–1 vs. ≥2), PINK score (0–1 vs. ≥2), NRI score (0–1 vs. ≥2), Ann Arbor stage (I/II vs. III/IV), primary tumor site (nasal vs. non-nasal), hemoglobin level (< 110 vs. ≥110 g/L), and EBV-DNA copy number (< 0.5 vs. ≥0.5 × 10³/ml) were significantly associated with 5-year overall survival (all P < 0.05). Multivariate analysis confirmed that ECOG score ≥ 2, presence of B symptoms, advanced Ann Arbor stage (III/IV), and high EBV-DNA copy number (≥ 0.5 × 10³/ml) were independent prognostic factors for worse survival. ECOG score, B symptoms, Ann Arbor stage, and EBV-DNA load serve as independent prognostic indicators in ENKTCL, providing critical information for risk stratification.