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<p>There is paucity of data regarding the role and relevance of a diagnostic splenectomy in the diagnosis of lymphoma. A total of 1165 splenectomies done between January 2008- June 2022, were screened for indication, and therapeutic /traumatic splenectomies (<i>n</i> = 1042) were excluded. The clinical spectrum and histopathology of 123 diagnostic splenectomies are described further. 75 (61%) patients were male with median age of 44 years (range 17–74). ‘B’ symptoms were present in 82 (66.7%). Lymphadenopathy was noted in 29 (23.9%) patients, though lymph nodes were not amenable for biopsy or biopsy was non-diagnostic. Preoperative factors including pre-surgical spleen size, lymphocytosis (&gt; 50%), serum LDH and bone marrow reports were analyzed. Splenic histopathology was diagnostic in 89 (72.3%) patients, lymphoma being the most common diagnosis(<i>n</i> = 72;58.5%). Amongst lymphomas, B-cell Non-Hodgkin lymphomas were most common (<i>n</i> = 48;66.6%). Subtyping of lymphoma was possible in 63 cases (87.5%). Splenic histopathology was diagnostic for rare neoplasms/diseases in 5 cases. On univariate analysis, none of the clinical or laboratory parameters were found to be predictive of a histopathological diagnosis of lymphoma. Diagnostic splenectomy has utility in the diagnosis of lymphoma and its subtyping; however, no clinical/laboratory parameters were predictive of a diagnosis of lymphoma.</p>

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Diagnostic Splenectomy: Clinical Profile, Role and Relevance in the Diagnosis of Lymphoma

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • Nutan Joshi,
  • Sujith Karumathil,
  • Sushil Selvarajan,
  • Kavitha M. Lakshmi,
  • S. Elanthenral,
  • Santhosh Raj,
  • Abi Manesh,
  • Divya Susanna Ninan,
  • Junita John,
  • Myla Jacob,
  • D. K. Titus,
  • Uday Kulkarni,
  • Biju George,
  • Aby Abraham,
  • Vikram Mathews,
  • Anu Korula

摘要

There is paucity of data regarding the role and relevance of a diagnostic splenectomy in the diagnosis of lymphoma. A total of 1165 splenectomies done between January 2008- June 2022, were screened for indication, and therapeutic /traumatic splenectomies (n = 1042) were excluded. The clinical spectrum and histopathology of 123 diagnostic splenectomies are described further. 75 (61%) patients were male with median age of 44 years (range 17–74). ‘B’ symptoms were present in 82 (66.7%). Lymphadenopathy was noted in 29 (23.9%) patients, though lymph nodes were not amenable for biopsy or biopsy was non-diagnostic. Preoperative factors including pre-surgical spleen size, lymphocytosis (> 50%), serum LDH and bone marrow reports were analyzed. Splenic histopathology was diagnostic in 89 (72.3%) patients, lymphoma being the most common diagnosis(n = 72;58.5%). Amongst lymphomas, B-cell Non-Hodgkin lymphomas were most common (n = 48;66.6%). Subtyping of lymphoma was possible in 63 cases (87.5%). Splenic histopathology was diagnostic for rare neoplasms/diseases in 5 cases. On univariate analysis, none of the clinical or laboratory parameters were found to be predictive of a histopathological diagnosis of lymphoma. Diagnostic splenectomy has utility in the diagnosis of lymphoma and its subtyping; however, no clinical/laboratory parameters were predictive of a diagnosis of lymphoma.